ReviewDiagnostics (Basel, Switzerland)2020
Diagnostic Problems in Diffuse Axonal Injury.
Review in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Differences in the Subcortical White Matter Integrity Based on the Disorder of Consciousness at the Chronic Stage of Diffuse Axonal Injury: A Tract-Based Spatial Statistics Study.Medicina (Kaunas, Lithuania) · 2026Article
- Prognostic Value of MRI Anatomical Radiologic Scores for One-Year Neurological Outcome After Severe Traumatic Brain Injury.Neurocritical care · 2026Observational
- The Dynamics of Neuroinflammation in Traumatic Brain Injury: Molecular Markers Useful for Establishing the Post-Traumatic Interval in Forensic Practice.International journal of molecular sciences · 2026Review
- A Novel snoRNA, Gm24418 Attenuates Inflammation Injury After Acute TBI Through Regulating CCL2.Journal of inflammation research · 2026Article
- Contusions bias cortical thickness estimates after traumatic brain injury: A TRACK-TBI study.NeuroImage. Clinical · 2026Article
- Fulminant cerebral fat embolism syndrome initially sparing the lungs after long-bone fractures: a case report of refractory status epilepticus.Frontiers in medicine · 2026Article
- Pathophysiological hypotheses of the triad in abusive infant shaking: A systematic review and analysis of corroborated cases.Forensic science international. Synergy · 2025Article
- Metabolomics Analysis Reveals Potential Biomarkers for Diffuse Axonal Injury Article Category: Original Work.Neurocritical care · 2025Article
- Evaluation of CT and MRI Radiomics for an Early Assessment of Diffuse Axonal Injury in Patients with Traumatic Brain Injury Compared to Conventional Radiological Diagnosis.Clinical neuroradiology · 2025Article
- Neurobiology of Chronic Pain, Posttraumatic Stress Disorder, and Mild Traumatic Brain Injury.Biology · 2025Review
- Partner-Inflicted Brain Injury: Intentional, Concurrent, and Repeated Traumatic and Hypoxic Neurologic Insults.Brain sciences · 2025Article
- Article
- Review
- White Matter Integrity and Motor Function Disruption Due to Traumatic Brain Injury in Piglets: Impacts on Motor-Related Brain Fibers.Brain sciences · 2024Article
- Influencing factors on neurological prognosis after traumatic brain injury and the role of brain tissue oxygen pressure (PbtOAmerican journal of translational research · 2024Article
- The Role of Novel Imaging and Biofluid Biomarkers in Traumatic Axonal Injury: An Updated Review.Biomedicines · 2023Review
- Physiotherapy Rehabilitation as an Adjunct to Functional Independence in Diffuse Axonal Injury: A Case Report.Cureus · 2022Article
- Traumatic Brain Injury After Music-Associated Head Banging: A Scoping Review.Archives of rehabilitation research and clinical translation · 2022Article
- Role of Diffusion Tensor Imaging in the Diagnosis of Traumatic Axonal Injury in Individual Patients with a Concussion or Mild Traumatic Brain Injury: A Mini-Review.Diagnostics (Basel, Switzerland) · 2022Review
- Hidden Truth in Cerebral Concussion-Traumatic Axonal Injury: A Narrative Mini-Review.Healthcare (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, three problems associated with diagnosing diffuse axonal injury (DAI) in patients with traumatic brain injury are reviewed: the shortage of scientific evidence supporting the 6-hour loss of consciousness (LOC) diagnostic criterion to discriminate concussion and DAI, the low sensitivity of conventional brain MRI in the detection of DAI lesions, and the inappropriateness of the term diffuse in DAI. Pathological study by brain biopsy is required to confirm DAI; however, performing a brain biopsy for the diagnosis of DAI in a living patient is impossible. Therefore, the diagnosis of DAI in a living patient is clinically determined based on the duration of LOC, clinical manifestations, and the results of conventional brain MRI. There is a shortage of scientific evidence supporting the use of the 6-hour LOC criterion to distinguish DAI from concussion, and axonal injuries have been detected in many concussion cases with a less than 6-hour LOC. Moreover, due to the low sensitivity of conventional brain MRI, which can only detect DAI lesions in approximately half of DAI patients, diagnostic MRI criteria for DAI are not well established. In contrast, diffusion tensor imaging (DTI) has been shown to have high sensitivity for the detection of DAI lesions. As DTI is a relatively new method, further studies aimed at the establishment of diagnostic criteria for DAI detection using DTI are needed. On the other hand, because DAI distribution is not diffuse but multifocal, and because axonal injury lesions have been detected in concussion patients, steps to standardize the use of terms related to axonal injury in both concussion and DAI are necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.