Evidence map›Paper›PMID 32098020›Full record

ArticleAntibiotics (Basel, Switzerland)2020

Modified Aminoglycosides Bind Nucleic Acids in High-Molecular-Weight Complexes.

Lanqing Ying, Hongkun Zhu, Marina Y Fosso, Sylvie Garneau-Tsodikova, Kurt Fredrick

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Interest of Homodialkyl Neamine Derivatives against ResistantInternational journal of molecular sciences · 2021
    Article
  2. Amphiphilic Aminoglycosides as Medicinal Agents.International journal of molecular sciences · 2020
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lanqing YingDepartment of Microbiology and Center for RNA Biology, The Ohio State University, Columbus, OH 43210-1292, USA.
Hongkun ZhuDepartment of Microbiology and Center for RNA Biology, The Ohio State University, Columbus, OH 43210-1292, USA.
Marina Y FossoDepartment of Pharmaceutical Sciences in the College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596, USA.
Sylvie Garneau-TsodikovaDepartment of Pharmaceutical Sciences in the College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596, USA.ORCID 0000-0002-7961-5555
Kurt FredrickDepartment of Microbiology and Center for RNA Biology, The Ohio State University, Columbus, OH 43210-1292, USA.
The Ohio State University · USUniversity of Kentucky · US

Funding

Molecular analysis of accurate ribosomal translocationR01GM072528 · NIGMS · OHIO STATE UNIVERSITY · PI Kurt L Fredrick · 2005 to 2026
$5.8M
Novel aminoglycoside adjuvants and stand-alone agents to combat tuberculosisR01AI090048 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARNEAU-TSODIKOVA, SYLVIE · 2011 to 2021
$4.4M
Bruker AVANCE NEO 600 MHz High-Performance Digital NMR SpectrometerS10OD028690 · OD · UNIVERSITY OF KENTUCKY · PI GARNEAU-TSODIKOVA, SYLVIE · 2020 to 2020
$1.4M
NIAID NIH HHS R01 AI090048NIGMS NIH HHS R01 GM072528NIH HHS AI090048NIH HHS GM072528NIH HHS S10 OD028690
6 · The paper itself

Abstract

Aminoglycosides represent a large group of antibiotics well known for their ability to target the bacterial ribosome. In studying 6"-substituted variants of the aminoglycoside tobramycin, we serendipitously found that compounds with C

Indexed as

DNAkanamycinreverse transcriptaseRNAtobramycin

Identifiers

PMID32098020
PMCPMC7168264
OpenAlexW3009037269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.