ArticleParkinsonism & related disorders2020
Increased on-state cortico-mesencephalic functional connectivity in Parkinson disease with freezing of gait.
Article in Parkinsonism & related disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional MRI in Parkinson's disease with freezing of gait: a systematic review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Brain modulation after exergaming training in advanced forms of Parkinson's disease: a randomized controlled study.Journal of neuroengineering and rehabilitation · 2024Trial
- Paired inhibitory stimulation and gait training modulates supplemental motor area connectivity in freezing of gait.Parkinsonism & related disorders · 2021Trial
- Longitudinal changes in effective connectivity associated with worsening freezing of gait in Parkinson's disease: a resting-state functional MRI study.Journal of neurology · 2026Observational
- The efficacy and safety of high-frequency SMA-rTMS on freezing of gait in patients with Parkinson's disease: a study protocol for a randomized controlled trial.BMC complementary medicine and therapies · 2026Article
- Neuromodulation of Cortical Targets in Freezing of Gait.The European journal of neuroscience · 2026Review
- Symptom-Specific Networks and the DBS-Modulated Network in Parkinson's Disease: A Connectivity-Based Review.Brain sciences · 2025Review
- Reduced automaticity in freezing of gait is associated with elevated cortico-cerebellar connectivity.Brain imaging and behavior · 2025Article
- Hot Topics and Frontiers of Resting-State fMRI in Parkinson's Disease: Research Trends and Paradigm Shifts From a Bibliometric Perspective.Parkinson's disease · 2025Review
- Knowledge mapping of freezing of gait in Parkinson's disease: a bibliometric analysis.Frontiers in neuroscience · 2024Article
- Subthalamic functional connectivity associated with freezing of gait dopa-response.Parkinsonism & related disorders · 2024Article
- Effects of task prioritization on a postural-motor task in early-stage Parkinson's disease: EEG connectivity and clinical implication.GeroScience · 2022Article
- Imaging the neural underpinnings of freezing of gait in Parkinson's disease.NeuroImage. Clinical · 2022Review
- Neurodegeneration of the Globus Pallidus Internus as a Neural Correlate to Dopa-Response in Freezing of Gait.Journal of Parkinson's disease · 2022Observational
- Executive function and dopamine response in Parkinson's disease freezing of gait.Parkinsonism & related disorders · 2021Article
- Functional Connectome in Parkinson's Disease and Parkinsonism.Current neurology and neuroscience reports · 2021Review
- More Than Just Static: Dynamic Functional Connectivity Changes of the Thalamic Nuclei to Cortex in Parkinson's Disease With Freezing of Gait.Frontiers in neurology · 2021Article
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5 authors.
Funding
Abstract
backgroundThe objective of this study was to evaluate ON-state resting state functional connectivity (FC) from the mesencephalic locomotor regions (MLR) to distributed sensorimotor cortical regions in patients with Freezing of Gait (FOG) and its association with gait performance.
methods54 individuals with PD were recruited for this study (50% of whom had FOG). All individuals received a resting state functional MRI in the ON state, and underwent a series of gait assessments during single and dual task conditions. FC with the MLR was calculated using a whole brain seed to voxel approach wherein the left and right MLR seeds were extracted from a published atlas. General linear regression was used to determine differences in connectivity between the individuals with ('freezers') and without ('non-freezers') FOG as well as the correlation between MLR connectivity and gait performance in the freezers.
resultsFreezers had significantly higher MLR connectivity to a network of sensorimotor regions compared to non-freezers. Additionally, among the freezers, higher FC with these regions was related to longer single-task and dual-task performance. There were no regions in which non-freezers had higher connectivity than freezers (p < 0.05, FWE corrected clusters for all analyses).
conclusionThese data support the hypothesis that freezers have significantly higher ON-state FC between the MLR and a network of cortical structures than non-freezers. Additionally, this elevated connectivity is directly related to worsening FOG severity. These data add to a theoretical foundation which suggests that cortical hyperconnectivity to the MLR is central to the underlying pathophysiology of FOG.
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