Evidence map›Paper›PMID 32097832›Full record

ReviewCurrent opinion in cell biology2020

Advances into understanding metabolites as signaling molecules in cancer progression.

Joyce Y Liu, Kathryn E Wellen

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
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  5. Article
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  10. Article
  11. Review
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  14. Review
  15. Acetyl-CoA metabolism in cancer.Nature reviews. Cancer · 2023
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Cancer metabolism: looking forward.Nature reviews. Cancer · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joyce Y LiuDepartment of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, 19104 PA, USA; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, 19104 PA, USA; Biochemistry & Molecular Biophysics Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, 19104 PA, USA.
Kathryn E WellenDepartment of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, 19104 PA, USA; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, 19104 PA, USA. Electronic address: wellenk@upenn.edu.
University of Pennsylvania · US

Funding

Role of acetyl-CoA in linking cancer cell metabolism and epigeneticsR01CA174761 · NCI · UNIVERSITY OF PENNSYLVANIA · PI WELLEN, KATHRYN ELAINE · 2014 to 2024
$3.6M
Acetyl-CoA metabolism and nutrient sensing in adipocytesR01DK116005 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GUERTIN, DAVID A, WELLEN, KATHRYN ELAINE · 2019 to 2022
$2.0M
Defining an acetyl-CoA sensing mechanism as a form of inter-organelle communication in cancerR01CA228339 · NCI · UNIVERSITY OF PENNSYLVANIA · PI WELLEN, KATHRYN ELAINE · 2018 to 2022
$1.9M
NCI NIH HHS R01 CA174761NCI NIH HHS R01 CA228339NIDDK NIH HHS R01 DK116005
6 · The paper itself

Abstract

Recent years have seen a great expansion in our knowledge of the roles that metabolites play in cellular signaling. Structural data have provided crucial insights into mechanisms through which amino acids are sensed. New nutrient-coupled protein and RNA modifications have been identified and characterized. A growing list of functions has been ascribed to metabolic regulation of modifications such as acetylation, methylation, and glycosylation. A current challenge lies in developing an integrated understanding of the roles that metabolic signaling mechanisms play in physiology and disease, which will inform the design of strategies to target such mechanisms. In this brief article, we review recent advances in metabolic signaling through post-translational modification during cancer progression, to provide a framework for understanding signaling roles of metabolites in the context of cancer biology and illuminate areas for future investigation.

Indexed as

AcetylationAnimalsDisease ProgressionGlycosylationHumansMetabolomeMethylationNeoplasm ProteinsNeoplasmsProtein Processing, Post-TranslationalSignal TransductionNeoplasm ProteinsCancerMetabolic signalingMetabolism

Identifiers

PMID32097832
PMCPMC7298879
OpenAlexW3007088172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.