Evidence map›Paper›PMID 32097814›Full record

ArticleEnvironmental research2020

Traffic-related particulate matter affects behavior, inflammation, and neural integrity in a developmental rodent model.

Benjamin C Nephew, Alexandra Nemeth, Neelakshi Hudda, Gillian Beamer, Phyllis Mann, Jocelyn Petitto, Ryan Cali, Marcelo Febo, Praveen Kulkarni, Guillaume Poirier and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Benjamin C NephewWorcester Polytechnic Institute, Department of Biology and Biotechnology, 100 Institute Rd, Worcester, MA, 01609, USA; University of Massachusetts Medical School, Department of Psychiatry, 55 N. Lake Road, Worcester, MA, 01655, USA. Electronic address: bcnephew@aol.com.
Alexandra NemethCummings School of Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, MA, 01536, USA.
Neelakshi HuddaDepartment of Civil and Environmental Engineering, Tufts University, 200 College Avenue, Medford, MA, 02155, USA.
Gillian BeamerCummings School of Veterinary Medicine, Department of Infectious Disease and Global Health, 200 Westboro Road, North Grafton, MA, 01536, USA.
Phyllis MannCummings School of Veterinary Medicine, Department of Biomedical Sciences, 200 Westboro Road, North Grafton, MA, 01536, USA.
Jocelyn PetittoWorcester Polytechnic Institute, Bioinformatics and Computational Biology Program, 100 Institute Rd, Worcester, MA, 01609, USA.
Ryan CaliWorcester Polytechnic Institute, Department of Biology and Biotechnology, 100 Institute Rd, Worcester, MA, 01609, USA; University of Massachusetts Medical School, Department of Psychiatry, 55 N. Lake Road, Worcester, MA, 01655, USA.
Marcelo FeboDepartment of Psychiatry, University of Florida, Gainesville, FL, 32610, USA.
Praveen KulkarniCenter for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
Guillaume PoirierUniversity of Massachusetts Medical School, Department of Psychiatry, 55 N. Lake Road, Worcester, MA, 01655, USA.
Jean KingWorcester Polytechnic Institute, Department of Biology and Biotechnology, 100 Institute Rd, Worcester, MA, 01609, USA; University of Massachusetts Medical School, Department of Psychiatry, 55 N. Lake Road, Worcester, MA, 01655, USA.
John L DurantDepartment of Civil and Environmental Engineering, Tufts University, 200 College Avenue, Medford, MA, 02155, USA; Department of Public Health and Community Medicine, Tufts University, 136 Harrison Avenue, Boston, MA, 02111, USA; Jonathan M. Tisch College of Civil Life, Tufts University, 10 Upper Campus Road, Medford, MA, 02155, USA.
Doug BruggeDepartment of Public Health Sciences, University of Connecticut, 195 Farmington Ave., Farmington, CT, 06032, USA.
Worcester Polytechnic Institute · USTufts University · USNew England Disabled Sports · USNortheastern University · USUniversity of Connecticut · USUniversity of Florida · USUniversity of Massachusetts Chan Medical School · US

Funding

NEAR Highway Pollution: From Research to ActionR01ES026980 · NIEHS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI BRUGGE, DOUG, REISNER, ELLIN · 2016 to 2020
$2.2M
4.7T Magnet System UpgradeS10OD018132 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KING, JEAN A · 2014 to 2014
$598k
NIEHS NIH HHS R01 ES026980NIH HHS S10 OD018132
6 · The paper itself

Abstract

Recent studies indicate that exposure to airborne particulate matter (PM) is associated with cognitive delay, depression, anxiety, autism, and neurodegenerative diseases; however, the role of PM in the etiology of these outcomes is not well-understood. Therefore, there is a need for controlled animal studies to better elucidate the causes and mechanisms by which PM impacts these health outcomes. We assessed the effects of gestational and early life exposure to traffic-related PM on social- and anxiety-related behaviors, cognition, inflammatory markers, and neural integrity in juvenile male rats. Gestating and lactating rats were exposed to PM from a Boston (MA, USA) traffic tunnel for 5 h/day, 5 days/week for 6 weeks (3 weeks gestation, 3 weeks lactation). The target exposure concentration for the fine fraction of nebulized PM, measured as PM2.5, was 200 μg/m

Indexed as

AnxietyAutism Spectrum DisorderNervous SystemParticulate MatterVehicle EmissionsAnimalsBostonDisease Models, AnimalFemaleInflammationLactationMaleRatsRodentiaSocial BehaviorParticulate MatterVehicle EmissionsBehaviorDevelopmentInflammationParticulate matterRodent

Identifiers

PMID32097814
PMCPMC7167358
OpenAlexW3008287292

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.