Evidence map›Paper›PMID 32097712›Full record

ArticleMicrobes and infection2020

Effects of IgG and IgM autoantibodies on non-infected erythrocytes is related to ABO blood group in Plasmodium vivax malaria and is associated with anemia.

Luiza Carvalho Mourão, Camila Maia Pantuzzo Medeiros, Gustavo Pereira Cardoso-Oliveira, Paula Magda da Silva Roma, Jamila da Silva Sultane Aboobacar, Beatriz Carolina Medeiros Rodrigues, Ubirajara Agero, Cor Jesus Fernandes Fontes, Érika Martins Braga

Abstract read
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In one paragraph

Article in Microbes and infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Luiza Carvalho MourãoDepartment of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: luizacmourao@hotmail.com.
Camila Maia Pantuzzo MedeirosDepartment of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: camilapantuzzo@gmail.com.
Gustavo Pereira Cardoso-OliveiraDepartment of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: gustavopcdom92@hotmail.com.
Paula Magda da Silva RomaDepartment of Physics, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: paula.magda.roma@hotmail.com.
Jamila da Silva Sultane AboobacarDepartment of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: jamilaaboobacar@gmail.com.
Beatriz Carolina Medeiros RodriguesDepartment of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: carolina.rodrigues2016@outlook.com.
Ubirajara AgeroDepartment of Physics, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: bira@ufmg.br.
Cor Jesus Fernandes FontesSchool of Medical Sciences, Universidade Federal de Mato Grosso, Cuiabá, MT, 78060-900, Brazil. Electronic address: corfontes@gmail.com.
Érika Martins BragaDepartment of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: embraga@icb.ufmg.br.
Universidade Federal de Minas Gerais · BRUniversidade Federal de Mato Grosso · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoantibodies play an important role in the destruction of non-infected red blood cells (nRBCs) during malaria. However, the relationship between this clearance and ABO blood groups is yet to be fully enlightened, especially for Plasmodium vivax infections. Here we show that anti-RBC IgG and IgM are increased in anemic patients with acute vivax malaria. Furthermore, both antibodies are able to decrease the deformability of nRBCs, but only IgG can induce in vitro erythrophagocytosis. Such effects are enhanced in type O erythrocytes, suggesting that individuals from this blood group infected with P. vivax malaria may be more susceptible to develop anemia.

Indexed as

ABO Blood-Group SystemAnemiaAutoantibodiesCell MembraneDisease SusceptibilityErythrocytesHumansImmunoglobulin GImmunoglobulin MMalaria, VivaxPhagocytosisPlasmodium vivaxABO Blood-Group SystemAutoantibodiesImmunoglobulin GImmunoglobulin MABO blood groupsIgGIgMMembrane deformabilityPhagocytosisPlasmodium vivax

Identifiers

PMID32097712
OpenAlexW3006879694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.