Evidence map›Paper›PMID 32097584›Full record

ArticleOpen biology2020

Wnt5b integrates Fak1a to mediate gastrulation cell movements via Rac1 and Cdc42.

I-Chen Hung, Tsung-Ming Chen, Jing-Ping Lin, Yu-Ling Tai, Tang-Long Shen, Shyh-Jye Lee

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Decoding Rho GTPase signalling networks in directed cell migration.Frontiers in cell and developmental biology · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. WNT5B in Physiology and Disease.Frontiers in cell and developmental biology · 2021
    Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

I-Chen HungDepartment of Life Science, National Taiwan University, No. 1, Roosevelt Road, Section 4, Taipei 10617, Taiwan.
Tsung-Ming ChenDepartment of Life Science, National Taiwan University, No. 1, Roosevelt Road, Section 4, Taipei 10617, Taiwan.
Jing-Ping LinDepartment of Plant Pathology and Microbiology, National Taiwan University, No. 1, Roosevelt Road, Section 4, Taipei 10617, Taiwan.
Yu-Ling TaiDepartment of Plant Pathology and Microbiology, National Taiwan University, No. 1, Roosevelt Road, Section 4, Taipei 10617, Taiwan.
Tang-Long ShenDepartment of Plant Pathology and Microbiology, National Taiwan University, No. 1, Roosevelt Road, Section 4, Taipei 10617, Taiwan.
Shyh-Jye LeeDepartment of Life Science, National Taiwan University, No. 1, Roosevelt Road, Section 4, Taipei 10617, Taiwan.
National Taiwan University · TWKaohsiung Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Focal adhesion kinase (FAK) mediates vital cellular pathways during development. Despite its necessity, how FAK regulates and integrates with other signals during early embryogenesis remains poorly understood. We found that the loss of Fak1a impaired epiboly, convergent extension and hypoblast cell migration in zebrafish embryos. We also observed a clear disturbance in cortical actin at the blastoderm margin and distribution of yolk syncytial nuclei. In addition, we investigated a possible link between Fak1a and a well-known gastrulation regulator, Wnt5b, and revealed that the overexpression of

Indexed as

ActinsAnimalscdc42 GTP-Binding ProteinCell LineCell MovementCRISPR-Cas SystemsFocal Adhesion Kinase 1GastrulationMiceMutationrac1 GTP-Binding ProteinSignal TransductionWnt-5a ProteinZebrafishZebrafish ProteinsActinscdc42 GTP-Binding ProteinFocal Adhesion Kinase 1rac1a protein, zebrafishrac1 GTP-Binding ProteinWnt-5a ProteinWnt5a protein, zebrafishZebrafish Proteinsactincell migrationconvergent extensionFAKgastrulationWnt

Identifiers

PMID32097584
PMCPMC7058935
OpenAlexW3008898663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.