ArticleBrain and behavior2020
Changes in mean platelet volume and hematologic indices in patients with panic disorder due to oxidative stress.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Plasma Tryptophan Hydroxylase 1 Activity-related Metabolic Markers and Stroke Risk: A Nested Case-control Study.Translational stroke research · 2026Article
- Article
- Lauric acid with or without levodopa ameliorates Parkinsonism in genetically modified model of Drosophila melanogaster via the oxidative-inflammatory-apoptotic pathway.Brain and behavior · 2024Article
- The impact of psychological stress on physiological indicators in healthcare workers: a cross-sectional study.Frontiers in public health · 2024Article
- The interplay between sexual abuse and inflammation, oxidative stress, and DNA damage in drug-naïve panic disorder patients.Molecular psychiatry · 2023Article
- Depression and Anxiety Symptoms Are Associated with Mean Platelet Volume in Autoimmune Disorders.International journal of environmental research and public health · 2022Article
- Elevated homocysteine, as a biomarker of cardiac injury, in panic disorder patients due to oxidative stress.Brain and behavior · 2020Article
- Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities.International journal of molecular sciences · 2020Review
- Changes in mean platelet volume and hematologic indices in patients with panic disorder due to oxidative stress.Brain and behavior · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveCardiovascular disorders are common in patients with panic disorder (PD), usually mediated by platelets. The present study was conducted to evaluate oxidative stress conditions and complete analysis of blood cells in patients with PD. SETTING AND SAMPLE POPULATION: Sixty healthy individuals and 60 patients were included in the study. Whole blood and serum samples were obtained from patients and controls. MATERIALS &
methodHematological studies, including blood cells count, hemoglobin, and hematocrit, were carried out on whole blood samples. In addition, oxidative stress indices including total antioxidant capacity, free oxygen species, and malondialdehyde concentration were measured in serum samples.
resultsResults showed that patients with PD had a significant increase in mean platelet volume index (MPV), platelet distribution width (PDW), red blood cell distribution width (RDW), and mean corpuscular hemoglobin concentration (MCHC) compared with healthy subjects (p < .05). Also, oxidative stress indices were significantly elevated in patients with PD compared with control group (p < .05).
conclusionElevated MPV is a hematologic indicator for patients with PD. This disorder may be caused by impaired serotonin metabolism, resulting in increased oxidative stress, as well as in platelet serotonin transporters. Regarding elevated oxidative stress, the risk of cardiovascular complications is high in patients with PD.
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