Evidence map›Paper›PMID 32097464›Full record

ArticleThe Journal of experimental medicine2020

Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain.

Jeroen F J Bogie, Elien Grajchen, Elien Wouters, Aida Garcia Corrales, Tess Dierckx, Sam Vanherle, Jo Mailleux, Pascal Gervois, Esther Wolfs, Jonas Dehairs and 12 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 146 citations in OpenAlex.

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  17. Cellular fibronectin exacerbates α-synuclein aggregation via integrin alpha4beta1 mediated PARP1 and SCD elevation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  18. Article
  19. Review
  20. Dysregulation of Monounsaturated Fatty Acids is Related to α-Synuclein in Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 4 countries.

Jeroen F J BogieDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Elien GrajchenDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Elien WoutersDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Aida Garcia CorralesDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Tess DierckxDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Sam VanherleDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Jo MailleuxDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Pascal GervoisDepartment of Cardio and Organ Systems, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Esther WolfsDepartment of Cardio and Organ Systems, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Jonas DehairsDepartment of Oncology, Laboratory of Lipid Metabolism and Cancer, Leuven Cancer Institute, University of Leuven, Leuven, Belgium.
Jana Van BroeckhovenDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Andrew P BowmanThe Maastricht MultiModal Molecular Imaging Institute, Division of Imaging Mass Spectrometry, Maastricht University, Maastricht, Netherlands.
Ivo LambrichtsDepartment of Cardio and Organ Systems, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Jan-Åke GustafssonCenter for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX.
Alan T RemaleyLipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Monique MulderDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.
Johannes V SwinnenDepartment of Oncology, Laboratory of Lipid Metabolism and Cancer, Leuven Cancer Institute, University of Leuven, Leuven, Belgium.
Mansour HaidarDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Shane R EllisThe Maastricht MultiModal Molecular Imaging Institute, Division of Imaging Mass Spectrometry, Maastricht University, Maastricht, Netherlands.
James M NtambiDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI.
Noam ZelcerDepartment of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Jerome J A HendriksDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Hasselt University · BEErasmus University Rotterdam · NLMaastricht University · NLAmsterdam UMC Location University of Amsterdam · NLErasmus MC · NLKarolinska Institutet · SENational Institutes of Health · USUniversity of Wisconsin–Madison · US

Funding

Role of Stearoyl-CoA Desaturase in MetabolismR01DK062388 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI NTAMBI, JAMES M. · 2002 to 2010
$2.6M
NIDDK NIH HHS R01 DK062388
6 · The paper itself

Abstract

Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. Macrophages and microglia are crucially involved in the formation and repair of demyelinated lesions. Here we show that myelin uptake temporarily skewed these phagocytes toward a disease-resolving phenotype, while sustained intracellular accumulation of myelin induced a lesion-promoting phenotype. This phenotypic shift was controlled by stearoyl-CoA desaturase-1 (SCD1), an enzyme responsible for the desaturation of saturated fatty acids. Monounsaturated fatty acids generated by SCD1 reduced the surface abundance of the cholesterol efflux transporter ABCA1, which in turn promoted lipid accumulation and induced an inflammatory phagocyte phenotype. Pharmacological inhibition or phagocyte-specific deficiency of Scd1 accelerated remyelination ex vivo and in vivo. These findings identify SCD1 as a novel therapeutic target to promote remyelination.

Indexed as

AnimalsATP Binding Cassette Transporter 1BrainCell LineCholesterolEndocytosisFatty AcidsFoam CellsHumansInflammationMacrophagesMiceMicrogliaMyelin SheathPhagocytesPhenotypeATP Binding Cassette Transporter 1CholesterolFatty AcidsProtein Kinase C-deltaStearoyl-CoA Desaturase

Identifiers

PMID32097464
PMCPMC7201924
OpenAlexW3008508106

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.