ArticlePLoS genetics2020
Octopamine neuron dependent aggression requires dVGLUT from dual-transmitting neurons.
Article in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Cellular and functional dissection of the octopaminergic and tyraminergic system in the Drosophila brain.Current biology : CB · 2026Article
- An octopamine-glutamate cotransmitting neuron gates aggressive escalation through layered inhibition inScience advances · 2026Article
- Article
- Octopamine regulates neural circuits in the mushroom body and central complex, influencing sleep and arousal.iScience · 2026Article
- Transcriptomic investigation of agonistic behaviors of boxer shrimps (Stenopus species): insights into the potential neural signaling roles of dopamine and acetylcholine.BMC genomics · 2026Article
- Frazzled/DCC directs spatial progenitor integration ensuring steady-state intestinal turnover.Nature communications · 2026Article
- Article
- High-throughput tracking of freely moving Drosophila reveals variations in aggression and courtship behaviors.Scientific reports · 2025Article
- Two classes of amine/glutamate multi-transmitter neurons innervate Drosophila internal male reproductive organs.bioRxiv : the preprint server for biology · 2025Article
- High-Throughput Tracking of Freely MovingbioRxiv : the preprint server for biology · 2025Article
- Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration.bioRxiv : the preprint server for biology · 2025Article
- Cholinergic and Glutamatergic Axons Differentially Require Glial Support in the Drosophila PNS.Glia · 2025Article
- Multimerized epitope tags for high-sensitivity protein detection.G3 (Bethesda, Md.) · 2025Article
- Modulating autism spectrum disorder pathophysiology using a trace amine-focused approach: targeting the gut.Molecular medicine (Cambridge, Mass.) · 2025Review
- Cell type-specific driver lines targeting theeLife · 2025Article
- Cell type-specific driver lines targeting thebioRxiv : the preprint server for biology · 2025Article
- Steroid hormone-induced wingless ligands tune female intestinal size in Drosophila.Nature communications · 2025Article
- Review
- Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion.PLoS biology · 2024Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Neuromodulators such as monoamines are often expressed in neurons that also release at least one fast-acting neurotransmitter. The release of a combination of transmitters provides both "classical" and "modulatory" signals that could produce diverse and/or complementary effects in associated circuits. Here, we establish that the majority of Drosophila octopamine (OA) neurons are also glutamatergic and identify the individual contributions of each neurotransmitter on sex-specific behaviors. Males without OA display low levels of aggression and high levels of inter-male courtship. Males deficient for dVGLUT solely in OA-glutamate neurons (OGNs) also exhibit a reduction in aggression, but without a concurrent increase in inter-male courtship. Within OGNs, a portion of VMAT and dVGLUT puncta differ in localization suggesting spatial differences in OA signaling. Our findings establish a previously undetermined role for dVGLUT in OA neurons and suggests that glutamate uncouples aggression from OA-dependent courtship-related behavior. These results indicate that dual neurotransmission can increase the efficacy of individual neurotransmitters while maintaining unique functions within a multi-functional social behavior neuronal network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.