ArticleShock (Augusta, Ga.)2020
Resuscitation From Hemorrhagic Shock With Fresh and Stored Blood and Polymerized Hemoglobin.
Article in Shock (Augusta, Ga.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Trial
- Lactate to hemoglobin ratio predicts short and long term mortality in critically ill patients with Gastrointestinal bleeding.Scientific reports · 2025Article
- Veterinary Perspectives on Hemoglobin-Based Oxygen Carriers in Experimental Hemorrhagic Shock: Insights from Rabbit Models.Veterinary sciences · 2025Article
- Systemically injected oxygen within rapidly dissolving microbubbles improves the outcomes of severe hypoxaemia in swine.Nature biomedical engineering · 2024Article
- A mathematical model of tissue axial and radial diffusion in the microvasculature for intravascular microscopy and phosphorescence quenching data.Computers in biology and medicine · 2024Article
- Polymerized human hemoglobin with low and high oxygen affinity in trauma models.Translational research : the journal of laboratory and clinical medicine · 2023Article
- Safety and efficacy of human polymerized hemoglobin on guinea pig resuscitation from hemorrhagic shock.Scientific reports · 2022Article
- Tangential flow filtration facilitated fractionation and PEGylation of low and high-molecular weight polymerized hemoglobins and their biophysical properties.Biotechnology and bioengineering · 2022Article
- Biophysical properties of tense quaternary state polymerized human hemoglobins bracketed between 500 kDa and 0.2 μm in size.Biotechnology progress · 2022Article
- Resuscitation from hemorrhagic shock after traumatic brain injury with polymerized hemoglobin.Scientific reports · 2021Article
- Comprehensive characterization of tense and relaxed quaternary state glutaraldehyde polymerized bovine hemoglobin as a function of cross-link density.Biotechnology and bioengineering · 2020Article
- Fluids of the Future.Frontiers in veterinary science · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundHemoglobin (Hb)-based oxygen carriers (HBOCs) have been proposed as alternatives to blood for decades. Previous studies demonstrated that large molecular diameter HBOCs based on polymerized bovine Hb (PolybHb) attenuate Hb side-effects and toxicity. The objective of this study was to test the safety and efficacy of tense state PolybHb after long-term storage. METHODS AND
resultsPolybHb was subjected to diafiltration to remove low molecular weight (< 500 kDa) species and stored for 2 years. PolybHb was studied in parallel with blood, collected from rats and stored leukodepleted under blood bank conditions for 3 weeks. Rats were hemorrhaged and resuscitated to 90% of the blood pressure before the hemorrhage with fresh blood, stored blood, fresh PolybHb, or 2-year-stored PolybHb. Hemorrhagic shock impaired oxygen delivery and cardiac function. Resuscitation restored blood pressure and cardiac function, but stored blood required a significantly larger transfusion volume to recover from shock compared with fresh blood and PolybHb (fresh and stored). Stored blood transfusion elevated markers of organ damage compared with all other groups.
conclusionsThese studies indicate that large molecular diameter PolybHb is as efficacious as fresh blood in restoring cardiac function and confirm the lack of degradation of PolybHb's safety or efficacy during long-term storage.
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