ArticleJournal of acquired immune deficiency syndromes (1999)2020
Brief Report: Linking Depressive Symptoms to Viral Nonsuppression Among Women With HIV Through Adherence Self-Efficacy and ART Adherence.
Article in Journal of acquired immune deficiency syndromes (1999), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Global Systematic Review of Common Mental Health Disorders in Adults Living with HIV.Current HIV/AIDS reports · 2021Pooled it
- Assessing longitudinal patterns of depressive symptoms and the influence of symptom trajectories on HIV pre-exposure prophylaxis adherence among adolescent girls in the HPTN 082 randomized controlled trial.Journal of the International AIDS Society · 2021Trial
- A Substance Abuse, Violence and Unhealthy Alcohol Use Syndemic Predicts Depression: A Longitudinal Study of Black Women Living With HIV in Four US Cities.Brain and behavior · 2026Article
- Unsuppressed viral load and its associated factors among people living with HIV on antiretroviral therapy: a cross-sectional study.BMC infectious diseases · 2026Article
- The kynurenine pathway in relation to depression and anhedonia symptom severity among women with HIV.Brain, behavior, & immunity - health · 2026Article
- Sociodemographic and clinical factors associated with use of depression treatment among people with HIV in the United States: An electronic health records-based cohort study.Journal of affective disorders · 2025Article
- Mammography Screening Among Women Living With HIV in the United States: A Quantitative Analysis of the Role of Health Care Empowerment.The Journal of the Association of Nurses in AIDS Care : JANAC · 2025Article
- How Does Poverty Stigma Affect Depression Symptoms for Women Living with HIV? Longitudinal Mediating and Moderating Mechanisms.International journal of mental health and addiction · 2025Article
- Patient-reported outcomes and experiences of migrants enrolled in a multidisciplinary HIV clinic with rapid, free, and onsite treatment dispensation: the 'ASAP' study.AIDS research and therapy · 2024Article
- Depression and HIV Care-seeking Behaviors in a Population-based Sample in North West Province, South Africa.AIDS and behavior · 2023Article
- HIV viral load suppression among people with mental disorders at two urban HIV clinics in Uganda: a parallel convergent mixed methods study using the social ecological model.AIDS research and therapy · 2023Article
- Perceived social support and depression among people living with HIV in China: roles of stigma and adherence self-efficacy.BMC psychiatry · 2023Article
- HIV viral load suppression among people with mental disorders at two urban HIV Clinics in Uganda: a parallel convergent mixed methods study using the Social Ecological Model.Research square · 2023Article
- Economic Well-being and Associated Mediating Pathways to Improved Antiretroviral Therapy Adherence Among Adolescents Living With HIV: A Prospective Cohort Study in South Africa.Journal of acquired immune deficiency syndromes (1999) · 2022Article
- Positive Psychological Factors and Life Themes in Relation to Health Outcomes in Women Living with HIV.International journal of behavioral medicine · 2022Article
- Depression and Viral Suppression Among Adults Living with HIV in Tanzania.AIDS and behavior · 2021Article
- Mechanisms from Food Insecurity to Worse HIV Treatment Outcomes in US Women Living with HIV.AIDS patient care and STDs · 2020Article
- Outcome expectancies toward adherence to antiretroviral therapy for pregnant and postpartum women with HIV.Women's health (London, England)Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundDepression plays a key role in suboptimal HIV outcomes, possibly mediated by adherence self-efficacy beliefs and antiretroviral treatment (ART) adherence behavior. Applying social-cognitive theory, we examined a longitudinal sequential path model of the association between depressive symptoms and viral nonsuppression in women with HIV (WWH) through these mediating mechanisms.
methodsThis was an observational longitudinal study using data from the Women's Adherence and Visit Engagement substudy of the Women's Interagency HIV Study. WWH (N = 375) completed measures of depressive symptoms, adherence self-efficacy, and ART adherence. Viral load was measured through blood draw. We examined a longitudinal sequential path model spanning 3 time points at least 6 months apart between 2015 and 2017. Indirect effects were assessed of depressive symptoms at time 1 (T1) on viral nonsuppression at T3 through adherence self-efficacy at T2 and ART adherence at T3. Covariates included age, income, recreational drug use, race, and months on ART.
resultsDepressive symptoms were associated with subsequent viral nonsuppression through its association with adherence self-efficacy and ART adherence [indirect effect: adjusted odds ratio = 1.004, 95% confidence interval: (1.001 to 1.008)]. Months on ART and recreational drug use were also significantly associated with viral nonsuppression at T3.
conclusionsOur findings support depressive symptoms' association with adherence self-efficacy that in turn lead to suboptimal ART adherence and ultimately to viral nonsuppression for WWH. Tailoring of interventions aimed at addressing depressive symptoms, substance use, and adherence self-efficacy among WWH is needed to help close the gap between ART prescription and viral suppression on the HIV care continuum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.