ArticleMicrobial biotechnology2021
Engineering thermophilic Geobacillus thermoglucosidasius for riboflavin production.
Article in Microbial biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Engineering Bacillus Subtilis for Efficient Biosynthesis of Riboflavin: Current Knowledge and Future Perspectives.Applied biochemistry and biotechnology · 2026Review
- Genome-wide analysis reveals structured ecological and functional divergence within Geobacillus stearothermophilus.Scientific reports · 2026Article
- Biosynthesis, Regulation, and Biotechnological Production Strategies of Riboflavin (Vitamin BPharmaceuticals (Basel, Switzerland) · 2026Review
- The engineering toolbox of Parageobacillus thermoglucosidasius.Applied microbiology and biotechnology · 2025Review
- Natural pigments derived from plants and microorganisms: classification, biosynthesis, and applications.Plant biotechnology journal · 2025Review
- Exploitation of Biodiversity in Bioeconomy: Examples, Opportunities, and Challenges.Advances in biochemical engineering/biotechnology · 2025Review
- Development of a xylose-inducible and glucose-insensitive expression system for Parageobacillus thermoglucosidasius.Applied microbiology and biotechnology · 2024Article
- Development of a thermophilic host-vector system for the production of recombinant proteins at elevated temperatures.Applied microbiology and biotechnology · 2023Article
- A thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering.Nature communications · 2023Article
- Functional characterization of the phosphotransferase system in Parageobacillus thermoglucosidasius.Scientific reports · 2023Article
- Metabolic engineering of thermophilic Bacillus methanolicus for riboflavin overproduction from methanol.Microbial biotechnology · 2023Article
- Advances in the optimization of central carbon metabolism in metabolic engineering.Microbial cell factories · 2023Review
- Application of multi-omic features clustering and pathway enrichment to clarify the impact of vitamin B2 supplementation on broiler caeca microbiome.Frontiers in microbiology · 2023Article
- Genome-scale reconstruction and metabolic modelling of the fast-growing thermophileMetabolic engineering communications · 2022Article
- Current status and applications of genus Geobacillus in the production of industrially important products-a review.Folia microbiologica · 2022Review
- Screening and engineering of high-activity promoter elements through transcriptomics and red fluorescent protein visualization inSynthetic and systems biotechnology · 2021Article
- Engineering thermophilic Geobacillus thermoglucosidasius for riboflavin production.Microbial biotechnology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The potential advantages for fermentation production of chemicals at high temperatures are attractive, such as promoting the rate of biochemical reactions, reducing the risk of contamination and the energy consumption for fermenter cooling. In this work, we de novo engineered the thermophile Geobacillus thermoglucosidasius to produce riboflavin, since this bacterium can ferment diverse carbohydrates at an optimal temperature of 60°C with a high growth rate. We first introduced a heterogeneous riboflavin biosynthetic gene cluster and enabled the strain to produce detectable riboflavin (28.7 mg l
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