ArticleMolecular biology and evolution2020
Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird.
Article in Molecular biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Evolutionary Response Patterns of the RodentEcology and evolution · 2026Article
- Livestock immunomodulators as alternatives to antimicrobials - a roadmap for the fight against drug resistance.BMC veterinary research · 2026Review
- Divergent cis-regulatory haplotypes at Tlr2 are associated with immune responsiveness.Molecular biology and evolution · 2026Article
- Integrative evidence reveals adaptive divergence and speciation in gentoo penguins.Communications biology · 2026Article
- Out of the shed and into the field: an immune toolkit for measuring wild ungulate immune phenotypes at multiple scales.Discovery immunology · 2026Article
- Associations among MHC genes, latitude, and avian malaria infections in the rufous-collared sparrow (Ecology and evolution · 2024Article
- Genetic variation at innate and adaptive immune genes - contrasting patterns of differentiation and local adaptation in a wild gull.Heredity · 2023Article
- Understanding the evolution of immune genes in jawed vertebrates.Journal of evolutionary biology · 2023Review
- Genomic insights into the secondary aquatic transition of penguins.Nature communications · 2022Article
- Host control and the evolution of cooperation in host microbiomes.Nature communications · 2022Article
- Selection Balancing at Innate Immune Genes: Adaptive Polymorphism Maintenance in Toll-Like Receptors.Molecular biology and evolution · 2022Review
- Positive selection over the mitochondrial genome and its role in the diversification of gentoo penguins in response to adaptation in isolation.Scientific reports · 2022Article
- Adaptation and Cryptic Pseudogenization in Penguin Toll-Like Receptors.Molecular biology and evolution · 2022Article
- Functional immunogenetic variation, rather than local adaptation, predicts ectoparasite infection intensity in a model fish species.Molecular ecology · 2021Article
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Authors and funding
20 authors at 12 institutions in 9 countries.
Funding
Abstract
Over evolutionary time, pathogen challenge shapes the immune phenotype of the host to better respond to an incipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation because of its circumpolar distribution over a large latitudinal range, with little or no admixture between different clades. In this study, we examine the diversity in a key family of innate immune genes-the Toll-like receptors (TLRs)-across the range of the Gentoo penguin. The three TLRs that we investigated present varying levels of diversity, with TLR4 and TLR5 greatly exceeding the diversity of TLR7. We present evidence of positive selection in TLR4 and TLR5, which points to pathogen-driven adaptation to the local pathogen milieu. Finally, we demonstrate that two positively selected cosegregating sites in TLR5 are sufficient to alter the responsiveness of the receptor to its bacterial ligand, flagellin. Taken together, these results suggest that Gentoo penguins have experienced distinct pathogen-driven selection pressures in different environments, which may be important given the role of the Gentoo penguin as a sentinel species in some of the world's most rapidly changing environments.
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