Evidence map›Paper›PMID 32096822›Full record

ArticleBioscience reports2020

MicroRNA-129-5p alleviates spinal cord injury in mice via suppressing the apoptosis and inflammatory response through HMGB1/TLR4/NF-κB pathway.

Guang Wan, Yongbo An, Jingang Tao, Yanli Wang, Qinglan Zhou, Rongli Yang, Qiudong Liang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Protective effect ofToxicology reports · 2024
    Article
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  10. Review
  11. Article
  12. Review
  13. Article
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  16. Review
  17. Review
  18. Review
  19. Role of microRNA-129 in cancer and non-cancerous diseases (Review).Experimental and therapeutic medicine · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Guang WanDepartment of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan, China.
Yongbo AnDepartment of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan, China.
Jingang TaoDepartment of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan, China.
Yanli WangOperation Room,The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan, China.
Qinglan ZhouDepartment of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan, China.
Rongli YangDepartment of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan, China.
Qiudong LiangDepartment of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan, China.
First Affiliated Hospital of Xinxiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secondary injury after spinal cord injury (SCI) is one reversible pathological change mainly involving excessive inflammatory response and neuro-apoptosis. Since in recent years, microRNAs (miRNAs) have been proposed as novel regulators of inflammation in different disease conditions. However, the role of miRNAs in the inflammatory response and apoptosis of secondary injury after SCI remains to be fully elucidated. Here, we tried to explore the influence and mechanism of miRNAs on the neuron inflammatory response and apoptosis after SCI. The expression profiles of miRNA were examined using miRNA microarray, and among the candidate miRNAs, miR-129-5p was found to be the most down-regulated miRNA in spinal tissues. Overexpression of miR-129-5p using agomir-miR-129-5p promoted injury mice functional recovery, suppressed the apoptosis and alleviated inflammatory response in spinal tissues. Using LPS-induced BV-2 cell model, we found miR-129-5p was also proved in protecting inflammatory response and cell apoptosis in vitro. High-mobility group protein B1 (HMGB1), a well-known inflammatory mediator, was found to be directly targeted by miR-129-5p and it was associated with the inhibitory effect of miR-129-5p on the activation of toll-like receptor (TLR)-4 (TLR4)/ nuclear factor-κB (NF-κB) pathway in vitro and in vivo. Further experiments revealed that the anti-apoptosis and anti-inflammatory effects of miR-129-5p were reversed by HMGB1 overexpression in BV-2 cells. Collectively, these data revealed that miR-129-5p alleviated SCI in mice via suppressing the apoptosis and inflammatory response through HMGB1//TLR4/NF-κB pathway. Our data suggest that up-regulation of miR-129-5p may be a novel therapeutic target for SCI.

Indexed as

AnimalsApoptosisDisease Models, AnimalFemaleHMGB1 ProteinInflammationMaleMiceMice, Inbred C57BLMicroRNAsNF-kappa BSignal TransductionSpinal Cord InjuriesToll-Like Receptor 4HMGB1 ProteinHMGB1 protein, mouseMicroRNAsMIRN129 microRNA, mouseNF-kappa BTlr4 protein, mouseToll-Like Receptor 4HMGB1//TLR4/NF-κB pathwayinflammatory responsemiR-129-5pSpinal cord injury

Identifiers

PMID32096822
PMCPMC7069919
OpenAlexW3007228248

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.