ArticleeLife2020
Neural mechanisms of economic choices in mice.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Laminar architecture of a decision circuit in the mouse orbitofrontal cortex.Nature communications · 2026Article
- Representations of the intrinsic value of information in mouse orbitofrontal cortex.Nature neuroscience · 2026Article
- A corticostriatal circuit updates subjective beliefs about latent task states.bioRxiv : the preprint server for biology · 2026Article
- The Laminar Organization of a Decision Circuit in Orbitofrontal Cortex is Agnostic to the Variable Encoding Scheme.bioRxiv : the preprint server for biology · 2026Article
- Reference-point dependent reinforcement learning in humans and rats.Nature communications · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Dopaminergic responses to identity prediction errors depend differently on the orbitofrontal cortex and hippocampus.Behavioral neuroscience · 2026Article
- Complementary yet Dissociable Influences of Medial and Lateral Orbitofrontal Cortex over Cue-Guided Decisions Involving Reward Magnitude and Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.bioRxiv : the preprint server for biology · 2025Article
- Article
- The orbitofrontal cortex updates beliefs for state inference.bioRxiv : the preprint server for biology · 2025Article
- The representation of decision variables in orbitofrontal cortex is longitudinally stable.Cell reports · 2024Article
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- Article
- The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors.Neurobiology of learning and memory · 2023Review
- Orbitofrontal cortex control of striatum leads economic decision-making.Nature neuroscience · 2023Article
- Mouse Behavior on the Trial-Unique Nonmatching-to-Location (TUNL) Touchscreen Task Reflects a Mixture of Distinct Working Memory Codes and Response Biases.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
Economic choices entail computing and comparing subjective values. Evidence from primates indicates that this behavior relies on the orbitofrontal cortex. Conversely, previous work in rodents provided conflicting results. Here we present a mouse model of economic choice behavior, and we show that the lateral orbital (LO) area is intimately related to the decision process. In the experiments, mice chose between different juices offered in variable amounts. Choice patterns closely resembled those measured in primates. Optogenetic inactivation of LO dramatically disrupted choices by inducing erratic changes of relative value and by increasing choice variability. Neuronal recordings revealed that different groups of cells encoded the values of individual options, the binary choice outcome and the chosen value. These groups match those previously identified in primates, except that the neuronal representation in mice is spatial (in monkeys it is good-based). Our results lay the foundations for a circuit-level analysis of economic decisions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.