ArticleRadiology2020
Heart Rate-Independent 3D Myocardial Blood Oxygen Level-Dependent MRI at 3.0 T with Simultaneous
Registry-linked trialOpen access · greenAbstract readValidation Study
In one paragraph
Article in Radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06000540 (A Prospective Pilot Study to Evaluate the Safety, Tolerability and Efficacy of Utilizing Precise Computer Controlled Gas Challenge in Healthy Subjects for Identification of Coronary Artery Disease), which is not on this map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Pilot Study to Evaluate the Safety, Tolerability and Efficacy of Utilizing Precise Computer Controlled Gas Challenge in Healthy Subjects for Identification of Coronary Artery Disease
Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- The association between cardiac T2*BOLD and quantitative flow ratio (QFR) in the diagnosis of stenotic coronary arteries in patients with multi-vessel coronary artery disease.La Radiologia medica · 2024Article
- Reliable Off-Resonance Correction in High-Field Cardiac MRI Using Autonomous Cardiac BBioengineering (Basel, Switzerland) · 2024Article
- Ultra-high field cardiac MRI in large animals and humans for translational cardiovascular research.Frontiers in cardiovascular medicine · 2023Article
- Myocardial blood flow is the dominant factor influencing cardiac magnetic resonance adenosine stress T2.NMR in biomedicine · 2022Article
- Advances in translational imaging of the microcirculation.Microcirculation (New York, N.Y. : 1994) · 2021Review
Corrections and comments
- Commented on by
Authors and funding
13 authors at 1 institution in 1 country.
Hsin-Jung YangFrom the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, PACT Bldg-Suite 400, 8700 Beverly Blvd, Los Angeles, CA 90048 (H.J.Y., D.D., B.S., I.C., R.T., P.S., R.D.); Department of Bioengineering (H.J.Y., R.D.) and David Geffen School of Medicine (D.D., P.S.), University of California, Los Angeles Calif; Lawson Health Research Institute, London, Canada (J.S., J.B., H.B., M.K., F.S.P.); and MR R&D, Siemens Healthcare, Los Angeles, Calif (X.B.).ORCID 0000-0001-9379-5495
Damini DeyFrom the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, PACT Bldg-Suite 400, 8700 Beverly Blvd, Los Angeles, CA 90048 (H.J.Y., D.D., B.S., I.C., R.T., P.S., R.D.); Department of Bioengineering (H.J.Y., R.D.) and David Geffen School of Medicine (D.D., P.S.), University of California, Los Angeles Calif; Lawson Health Research Institute, London, Canada (J.S., J.B., H.B., M.K., F.S.P.); and MR R&D, Siemens Healthcare, Los Angeles, Calif (X.B.).ORCID 0000-0003-2236-6970
Jane SykesFrom the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, PACT Bldg-Suite 400, 8700 Beverly Blvd, Los Angeles, CA 90048 (H.J.Y., D.D., B.S., I.C., R.T., P.S., R.D.); Department of Bioengineering (H.J.Y., R.D.) and David Geffen School of Medicine (D.D., P.S.), University of California, Los Angeles Calif; Lawson Health Research Institute, London, Canada (J.S., J.B., H.B., M.K., F.S.P.); and MR R&D, Siemens Healthcare, Los Angeles, Calif (X.B.).ORCID 0000-0001-9058-5062
John ButlerFrom the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, PACT Bldg-Suite 400, 8700 Beverly Blvd, Los Angeles, CA 90048 (H.J.Y., D.D., B.S., I.C., R.T., P.S., R.D.); Department of Bioengineering (H.J.Y., R.D.) and David Geffen School of Medicine (D.D., P.S.), University of California, Los Angeles Calif; Lawson Health Research Institute, London, Canada (J.S., J.B., H.B., M.K., F.S.P.); and MR R&D, Siemens Healthcare, Los Angeles, Calif (X.B.).ORCID 0000-0001-7407-0990
Heather BiernaskiFrom the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, PACT Bldg-Suite 400, 8700 Beverly Blvd, Los Angeles, CA 90048 (H.J.Y., D.D., B.S., I.C., R.T., P.S., R.D.); Department of Bioengineering (H.J.Y., R.D.) and David Geffen School of Medicine (D.D., P.S.), University of California, Los Angeles Calif; Lawson Health Research Institute, London, Canada (J.S., J.B., H.B., M.K., F.S.P.); and MR R&D, Siemens Healthcare, Los Angeles, Calif (X.B.).ORCID 0000-0002-9018-3298
Michael KovacsFrom the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, PACT Bldg-Suite 400, 8700 Beverly Blvd, Los Angeles, CA 90048 (H.J.Y., D.D., B.S., I.C., R.T., P.S., R.D.); Department of Bioengineering (H.J.Y., R.D.) and David Geffen School of Medicine (D.D., P.S.), University of California, Los Angeles Calif; Lawson Health Research Institute, London, Canada (J.S., J.B., H.B., M.K., F.S.P.); and MR R&D, Siemens Healthcare, Los Angeles, Calif (X.B.).
Xiaoming BiFrom the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, PACT Bldg-Suite 400, 8700 Beverly Blvd, Los Angeles, CA 90048 (H.J.Y., D.D., B.S., I.C., R.T., P.S., R.D.); Department of Bioengineering (H.J.Y., R.D.) and David Geffen School of Medicine (D.D., P.S.), University of California, Los Angeles Calif; Lawson Health Research Institute, London, Canada (J.S., J.B., H.B., M.K., F.S.P.); and MR R&D, Siemens Healthcare, Los Angeles, Calif (X.B.).ORCID 0000-0001-6286-9172
Behzad SharifFrom the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, PACT Bldg-Suite 400, 8700 Beverly Blvd, Los Angeles, CA 90048 (H.J.Y., D.D., B.S., I.C., R.T., P.S., R.D.); Department of Bioengineering (H.J.Y., R.D.) and David Geffen School of Medicine (D.D., P.S.), University of California, Los Angeles Calif; Lawson Health Research Institute, London, Canada (J.S., J.B., H.B., M.K., F.S.P.); and MR R&D, Siemens Healthcare, Los Angeles, Calif (X.B.).ORCID 0000-0002-8945-8178
Ivan CokicFrom the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, PACT Bldg-Suite 400, 8700 Beverly Blvd, Los Angeles, CA 90048 (H.J.Y., D.D., B.S., I.C., R.T., P.S., R.D.); Department of Bioengineering (H.J.Y., R.D.) and David Geffen School of Medicine (D.D., P.S.), University of California, Los Angeles Calif; Lawson Health Research Institute, London, Canada (J.S., J.B., H.B., M.K., F.S.P.); and MR R&D, Siemens Healthcare, Los Angeles, Calif (X.B.).
Richard TangFrom the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, PACT Bldg-Suite 400, 8700 Beverly Blvd, Los Angeles, CA 90048 (H.J.Y., D.D., B.S., I.C., R.T., P.S., R.D.); Department of Bioengineering (H.J.Y., R.D.) and David Geffen School of Medicine (D.D., P.S.), University of California, Los Angeles Calif; Lawson Health Research Institute, London, Canada (J.S., J.B., H.B., M.K., F.S.P.); and MR R&D, Siemens Healthcare, Los Angeles, Calif (X.B.).ORCID 0000-0002-7139-7493
Piotr SlomkaFrom the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, PACT Bldg-Suite 400, 8700 Beverly Blvd, Los Angeles, CA 90048 (H.J.Y., D.D., B.S., I.C., R.T., P.S., R.D.); Department of Bioengineering (H.J.Y., R.D.) and David Geffen School of Medicine (D.D., P.S.), University of California, Los Angeles Calif; Lawson Health Research Institute, London, Canada (J.S., J.B., H.B., M.K., F.S.P.); and MR R&D, Siemens Healthcare, Los Angeles, Calif (X.B.).ORCID 0000-0002-6110-938X
Frank S PratoFrom the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, PACT Bldg-Suite 400, 8700 Beverly Blvd, Los Angeles, CA 90048 (H.J.Y., D.D., B.S., I.C., R.T., P.S., R.D.); Department of Bioengineering (H.J.Y., R.D.) and David Geffen School of Medicine (D.D., P.S.), University of California, Los Angeles Calif; Lawson Health Research Institute, London, Canada (J.S., J.B., H.B., M.K., F.S.P.); and MR R&D, Siemens Healthcare, Los Angeles, Calif (X.B.).ORCID 0000-0002-4592-2522
Rohan DharmakumarFrom the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, PACT Bldg-Suite 400, 8700 Beverly Blvd, Los Angeles, CA 90048 (H.J.Y., D.D., B.S., I.C., R.T., P.S., R.D.); Department of Bioengineering (H.J.Y., R.D.) and David Geffen School of Medicine (D.D., P.S.), University of California, Los Angeles Calif; Lawson Health Research Institute, London, Canada (J.S., J.B., H.B., M.K., F.S.P.); and MR R&D, Siemens Healthcare, Los Angeles, Calif (X.B.).ORCID 0000-0003-4120-4635
Cedars-Sinai Medical Center · US
Funding
Reliable Evaluation of Coronary Artery Disease using Myocardial BOLD MRI with CO2R01HL091989 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DHARMAKUMAR, ROHAN · 2008 to 2016
$3.5MNHLBI NIH HHS R01 HL091989
Abstract
Background Despite advances, blood oxygen level-dependent (BOLD) cardiac MRI for myocardial perfusion is limited by inadequate spatial coverage, imaging speed, multiple breath holds, and imaging artifacts, particularly at 3.0 T. Purpose To develop and validate a robust, contrast agent-unenhanced, free-breathing three-dimensional (3D) cardiac MRI approach for reliably examining changes in myocardial perfusion between rest and adenosine stress. Materials and Methods A heart rate-independent, free-breathing 3D T2 mapping technique at 3.0 T that can be completed within the period of adenosine stress (≤4 minutes) was developed by using computer simulations, ex vivo heart preparations, and dogs. Studies in dogs were performed with and without coronary stenosis and validated with simultaneously acquired nitrogen 13 (
Indexed as
Heart RateImaging, Three-DimensionalPositron-Emission TomographyAdenosineAdultAmmoniaAnimalsCardiac Imaging TechniquesContrast MediaCoronary StenosisDogsExercise TestFemaleHeartHumansMagnetic Resonance ImagingAdenosineAmmoniaContrast MediaNitrogen-13Nitrogen RadioisotopesOxygen
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT06000540ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.