ArticleeLife2020
An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in
Abstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Partitioning of the truncated insulin receptor DAF-2B between homodimers and heterodimers influences insulin signaling in C. elegans.PLoS genetics · 2026Article
- An in vivo parallelized reporter assay to uncover tissue-specific splicing regulatory sequences in a multicellular animal.Nucleic acids research · 2026Article
- Nematode extracellular protein interactome expands connections between signaling pathways.Cell genomics · 2026Article
- Full-length direct RNA sequencing reveals extensive remodeling of RNA expression, processing and modification in aging Caenorhabditis elegans.Nucleic acids research · 2024Article
- Catalytic activities of wild-type C. elegans DAF-2 kinase and dauer-associated mutants.The FEBS journal · 2024Article
- The Fourth Annual Symposium of the Midwest Aging Consortium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Full-length direct RNA sequencing reveals extensive remodeling of RNA expression, processing and modification in agingbioRxiv : the preprint server for biology · 2024Article
- Distinct neurogenetic mechanisms establish the same chemosensory valence state at different life stages in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2024Article
- Exploring diabesity pathophysiology through proteomic analysis usingFrontiers in endocrinology · 2024Article
- Retinoid X receptor heterodimers in hepatic function: structural insights and therapeutic potential.Frontiers in pharmacology · 2024Review
- ADAR-mediated regulation of PQM-1 expression in neurons impacts gene expression throughout C. elegans and regulates survival from hypoxia.PLoS biology · 2023Article
- The SR protein RSP-2 influences expression of the truncated insulin receptor DAF-2B in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2023Article
- The C. elegans truncated insulin receptor DAF-2B regulates survival of L1 arrested larvae.PloS one · 2023Article
- DAF-2/insulin IGF-1 receptor regulates motility during aging by integrating opposite signaling from muscle and neuronal tissues.Aging cell · 2022Article
- Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ.Nature communications · 2022Article
- Using population selection and sequencing to characterize natural variation of starvation resistance ineLife · 2022Article
- Splicing alterations in healthy aging and disease.Wiley interdisciplinary reviews. RNA · 2021Review
- An automated platform to monitor long-term behavior and healthspan in Caenorhabditis elegans under precise environmental control.Communications biology · 2020Article
- Short and sweet.eLife · 2020Article
Corrections and comments
- Commented on byShort and sweet.2020
Authors and funding
10 authors.
Bryan A Martinez *Department of Molecular Medicine, The Scripps Research Institute - Scripps Florida, Jupiter, United States.
Pedro Reis Rodrigues *Department of Molecular Medicine, The Scripps Research Institute - Scripps Florida, Jupiter, United States.
Ricardo M Nuñez MedinaDepartment of Molecular Medicine, The Scripps Research Institute - Scripps Florida, Jupiter, United States.
Prosenjit MondalDepartment of Molecular Medicine, The Scripps Research Institute - Scripps Florida, Jupiter, United States.
Neale J HarrisonDepartment of Molecular Medicine, The Scripps Research Institute - Scripps Florida, Jupiter, United States.ORCID 0000-0001-6821-4089
Museer A LoneDepartment of Molecular Medicine, The Scripps Research Institute - Scripps Florida, Jupiter, United States.
Amanda WebsterDepartment of Molecular Medicine, The Scripps Research Institute - Scripps Florida, Jupiter, United States.
Aditi U GurkarDepartment of Molecular Medicine, The Scripps Research Institute - Scripps Florida, Jupiter, United States.
Brock GrillDepartment of Neuroscience, The Scripps Research Institute - Scripps Florida, Jupiter, United States.ORCID 0000-0002-0379-3267
Matthew S GillDepartment of Molecular Medicine, The Scripps Research Institute - Scripps Florida, Jupiter, United States.ORCID 0000-0003-0818-8792
Funding
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6MMechanisms of synapse formation and axon termination in C. elegansR01NS072129 · NINDS · UNIVERSITY OF MINNESOTA · PI GRILL, BROCK · 2011 to 2024
$8.0MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5MGenetic analysis of a truncated insulin receptor.R01DK108801 · NIDDK · UNIVERSITY OF MINNESOTA · PI GILL, MATTHEW SIMON · 2018 to 2021
$2.0MModulators of DNA damage associated nucleo-mitochondrial communication in agingR00AG049126 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GURKAR, ADITI U · 2017 to 2019
$835kGenetic and Molecular Analysis of a Novel Insulin Regulatory ProteinR21AG050172 · NIA · SCRIPPS FLORIDA · PI GILL, MATTHEW SIMON · 2017 to 2018
$524kNIA NIH HHS P30 AG024827NIA NIH HHS R00 AG049126NIA NIH HHS R21 AG050172NIDDK NIH HHS R01 DK108801NIH HHS P40 OD010440NINDS NIH HHS R01 NS072129
Abstract
In the nematode
Indexed as
Alternative SplicingAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsGenes, HelminthInsulinMutationReceptor, InsulinSignal TransductionCaenorhabditis elegans ProteinsDAF-2 protein, C elegansInsulinReceptor, Insulinagingalternative splicingC. elegansDAF-2dauer formationdevelopmental biologygeneticsgenomicsinsulin sensitivity
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.