ArticleNeuroscience bulletin2020
Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice.
Article in Neuroscience bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 31 citations in OpenAlex.
- Stress ensemble in the BNST mediates comorbid anxiety and sleep disruption.Science advances · 2026Article
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- Prostaglandin EThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Bright light treatment counteracts stress-induced sleep alterations in mice, via a visual circuit related to the rostromedial tegmental nucleus.PLoS biology · 2023Article
- Restraint stress induced anxiety and sleep in mice.Frontiers in psychiatry · 2023Article
- A noradrenergic-hypothalamic neural substrate for stress-induced sleep disturbances.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A specific circuit in the midbrain detects stress and induces restorative sleep.Science (New York, N.Y.) · 2022Article
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- A Standardized Protocol for the Induction of Specific Social Fear in Mice.Neuroscience bulletin · 2021Article
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- DeepBhvTracking: A Novel Behavior Tracking Method for Laboratory Animals Based on Deep Learning.Frontiers in behavioral neuroscience · 2021Article
- Stress-induced sleep-like inactivity modulates stress susceptibility in mice.Scientific reports · 2020Article
- Abnormal Sleep Signals Vulnerability to Chronic Social Defeat Stress.Frontiers in neuroscience · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social defeat stress (SDS) plays a major role in the pathogenesis of psychiatric disorders like anxiety and depression. Sleep is generally considered to involve recovery of the brain from prior experience during wakefulness and is altered after acute SDS. However, the effect of acute SDS on sleep/wake behavior in mice varies between studies. In addition, whether sleep changes in response to stress contribute to anxiety is not well established. Here, we first investigated the effects of acute SDS on sleep/wake states in the active period in mice. Our results showed that total sleep time (time in rapid eye-movement [REM] and non-REM [NREM] sleep) increased in the active period after acute SDS. NREM sleep increased mainly during the first 3 h after SDS, while REM sleep increased at a later time. Then, we demonstrated that the increased NREM sleep had an anxiolytic benefit in acute SDS. Mice deprived of sleep for 1 h or 3 h after acute SDS remained in a highly anxious state, while in mice with ad libitum sleep the anxiety rapidly faded away. Altogether, our findings suggest an anxiolytic effect of NREM sleep, and indicate a potential therapeutic strategy for anxiety.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.