Evidence map›Paper›PMID 32096011›Full record

ArticleEJNMMI research2020

Indium-111-labeled CD166-targeted peptide as a potential nuclear imaging agent for detecting colorectal cancer stem-like cells in a xenograft mouse model.

Siao-Syun Guan, Cheng-Tien Wu, Tse-Zung Liao, Tsai-Yueh Luo, Kun-Liang Lin, Shing-Hwa Liu

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Molecular Imaging of Cancer Stem Cells and Their Role in Therapy Resistance.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Review
  4. Cannot Target What Cannot Be Seen: Molecular Imaging of Cancer Stem Cells.International journal of molecular sciences · 2023
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Siao-Syun GuanInstitute of Nuclear Energy Research, Atomic Energy Council, Taoyuan, Taiwan.
Cheng-Tien WuDepartment of Nutrition, China Medical University, Taichung, 40402, Taiwan.
Tse-Zung LiaoInstitute of Nuclear Energy Research, Atomic Energy Council, Taoyuan, Taiwan.
Tsai-Yueh LuoInstitute of Nuclear Energy Research, Atomic Energy Council, Taoyuan, Taiwan.
Kun-Liang LinInstitute of Nuclear Energy Research, Atomic Energy Council, Taoyuan, Taiwan.
Shing-Hwa LiuInstitute of Toxicology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei, 10051, Taiwan. shinghwaliu@ntu.edu.tw.ORCID http://orcid.org/0000-0002-9976-1197
Atomic Energy Council · TWChina Medical University · TWNational Taiwan University · TW

Funding

Atomic Energy Council, Executive Yuan, Taiwan (R.O.C) 107-2001-02-17-03Ministry of Science and Technology, Taiwan MOST 106-3111-Y-042A-090
6 · The paper itself

Abstract

backgroundCancer stem cells (CSCs) are involved in drug resistance, metastasis, and relapse of cancers, which can significantly affect tumor therapy. Hence, to develop specifically therapeutic target probe at CSCs for improvement of survival and quality of life of cancer patients is urgently needed. The CD166 protein has been suggested to be involved in colorectal cancer (CRC) tumorigenesis and to be considered a marker for colorectal CSCs (CRCSCs) detection. In this study, therefore, we attend to apply a nuclear imaging agent probe, Glycine

resultsWe isolated the CD166-positive cells from the HCT15 CRC cell line (CD166

conclusionsOur results indicated that the indium-111-labeled CD166tp-G

Indexed as

Cancer stem cellsCD166-targeted peptidesColorectal cancerNuclear imaging agent probe

Identifiers

PMID32096011
PMCPMC7040160
OpenAlexW3012835612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.