ArticleBiomechanics and modeling in mechanobiology2020
Numerical evaluation of transcatheter aortic valve performance during heart beating and its post-deployment fluid-structure interaction analysis.
Article in Biomechanics and modeling in mechanobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 69 citations in OpenAlex.
- Hematologic complications and design challenges in cardiovascular devices.Communications engineering · 2026Review
- Fully coupled patient-specific fluid-structure interaction modeling of post-TAVI hemodynamics compared with echocardiographic measurements.Biomechanics and modeling in mechanobiology · 2026Article
- Development of a Polymeric TAVR Device Tailored to Bicuspid Aortic Valve Patients Using In Silico Design Optimization and Evaluation.Annals of biomedical engineering · 2026Article
- Article
- Computational modelling for personalized transcatheter aortic valve replacement planning: a systematic review of complications and decision support.Frontiers in digital health · 2026Review
- Predicting procedural outcomes in transcatheter aortic valve implantation: a scoping review of numerical patient-specific simulations.Progress in biomedical engineering (Bristol, England) · 2025Article
- Advanced Computer Simulation Based on Cardiac Imaging in Planning of Structural Heart Disease Interventions.Journal of clinical medicine · 2025Review
- Experimental Investigation of the Effect of a MitraClip on Left Ventricular Flow Dynamics.Annals of biomedical engineering · 2025Article
- Assessing post-TAVR cardiac conduction abnormalities risk using an electromechanically coupled beating heart.Biomechanics and modeling in mechanobiology · 2025Article
- Finite Element Analysis of Evolut Transcatheter Heart Valves: Effects of Aortic Geometries and Valve Sizes on Post-TAVI Wall Stresses and Deformations.Journal of clinical medicine · 2025Article
- Accuracy of Three-Dimensional Neo Left Ventricular Outflow Tract Simulations With Transcatheter Mitral Valve Replacement in Different Mitral Phenotypes.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Article
- Patient-Specific Numerical Simulations of Coronary Artery Hemodynamics and Biomechanics: A Pathway to Clinical Use.Cardiovascular engineering and technology · 2024Review
- Multiscale structure and function of the aortic valve apparatus.Physiological reviews · 2024Review
- Fluid-Solid Interaction Analysis for Developing In-Situ Strain and Flow Sensors for Prosthetic Valve Monitoring.Sensors (Basel, Switzerland) · 2024Article
- Effect of Sinotubular Junction Size on TAVR Leaflet Thrombosis: A Fluid-Structure Interaction Analysis.Annals of biomedical engineering · 2024Article
- Analysis of fibrocalcific aortic valve stenosis: computational pre-and-post TAVR haemodynamics behaviours.Royal Society open science · 2024Article
- Artificial Intelligence in Transcatheter Aortic Valve Replacement: Its Current Role and Ongoing Challenges.Diagnostics (Basel, Switzerland) · 2024Review
- In silico fatigue optimization of TAVR stent designs with physiological motion in a beating heart model.Computer methods and programs in biomedicine · 2024Article
- Latest Developments in Adapting Deep Learning for Assessing TAVR Procedures and Outcomes.Journal of clinical medicine · 2023Review
- Fluid-structure interaction modeling of compliant aortic valves using the lattice Boltzmann CFD and FEM methods.Biomechanics and modeling in mechanobiology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Transcatheter aortic valve replacement (TAVR) is a minimally invasive procedure that provides an effective alternative to open-heart surgical valve replacement for treating advanced calcific aortic valve disease patients. However, complications, such as valve durability, device migration, paravalvular leakage (PVL), and thrombogenicity may lead to increased overall post-TAVR morbidity and mortality. A series of numerical studies involving a self-expandable TAVR valve were performed to evaluate these complications. Structural studies were performed with finite element (FE) analysis, followed by computational fluid dynamics (CFD) simulations, and fluid-structure interaction (FSI) analysis. The FE analysis was utilized to study the effect of TAVR valve implantation depth on valve anchorage in the Living Heart Human Model, which is capable of simulating beating heart during repeated cardiac cycles. The TAVR deployment cases where no valve migration was observed were then used to calculate the post-deployment thrombogenic potential via CFD simulations. FSI analysis followed to further assess the post-deployment TAVR hemodynamic performance for different implantation depths. The deployed valves PVL, geometric and effective orifice areas, and the leaflets structural and flow stress magnitudes were compared to determine the device optimal landing zone. The combined structural and hemodynamic analysis indicated that with the TAVR valve deployed at an aft ventricle position an optimal performance was achieved in the specific anatomy studied. Given the TAVR's rapid expansion to younger lower-risk patients, the comprehensive numerical methodology proposed here can potentially be used as a predictive tool for both procedural planning and valve design optimization to minimize the reported complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.