ArticleNucleic acids research2020
The critical function of the plastid rRNA methyltransferase, CMAL, in ribosome biogenesis and plant development.
Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
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- 16S ribosomal RNA modification drives transcript-specific translation efficiency.bioRxiv : the preprint server for biology · 2026Article
- Genomic Insights Into a Hospital-Acquired High-Risk Vancomycin-Resistant Enterococcus faecium Outbreak in Guangdong, China.MicrobiologyOpen · 2026Article
- The chloroplast 16S rRNA dimethyltransferase BrPFC1 is required for Brassica rapa development under chilling stress.The Plant journal : for cell and molecular biology · 2025Article
- Sugarcane yellow leaf virus impairs the transcriptomic defense response of sugarcane to its new aphid vector Melanaphis sorghi.BMC plant biology · 2025Article
- Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance.Signal transduction and targeted therapy · 2025Review
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- The Roles of RNA Modifications in Regulating Chloroplast Performance and Photosynthesis Efficiency.International journal of molecular sciences · 2024Review
- SeqSNP-Based Targeted GBS Provides Insight into the Genetic Relationships among Global Collections ofGenes · 2024Article
- The uS10c-BPG2 module mediates ribosomal RNA processing in chloroplast nucleoids.Nucleic acids research · 2024Article
- Regulation of chloroplast biogenesis, development, and signaling by endogenous and exogenous cues.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- RNA methylation in plants: An overview.Frontiers in plant science · 2023Review
- Auxin inhibits chlorophyll accumulation through ARF7-IAA14-mediated repression of chlorophyll biosynthesis genes inFrontiers in plant science · 2023Article
- MraZ Transcriptionally Controls the Critical Level of FtsL Required for Focusing Z-Rings and Kickstarting Septation in Bacillus subtilis.Journal of bacteriology · 2022Article
- Epitranscriptomics: An Additional Regulatory Layer in Plants' Development and Stress Response.Plants (Basel, Switzerland) · 2022Review
- Morphological characterization and transcriptome analysis of leaf angle mutantFrontiers in plant science · 2022Article
- AtRsmD Is Required for Chloroplast Development and Chloroplast Function inFrontiers in plant science · 2022Article
- Fine-Mapping and Functional Analyses of a Candidate Gene Controlling Isoflavone Content in Soybeans Seed.Frontiers in plant science · 2022Article
- RNA methylation in chloroplasts or mitochondria in plants.RNA biology · 2021Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methylation of nucleotides in ribosomal RNAs (rRNAs) is a ubiquitous feature that occurs in all living organisms. The formation of methylated nucleotides is performed by a variety of RNA-methyltransferases. Chloroplasts of plant cells result from an endosymbiotic event and possess their own genome and ribosomes. However, enzymes responsible for rRNA methylation and the function of modified nucleotides in chloroplasts remain to be determined. Here, we identified an rRNA methyltransferase, CMAL (Chloroplast MraW-Like), in the Arabidopsis chloroplast and investigated its function. CMAL is the Arabidopsis ortholog of bacterial MraW/ RsmH proteins and accounts to the N4-methylation of C1352 in chloroplast 16S rRNA, indicating that CMAL orthologs and this methyl-modification nucleotide is conserved between bacteria and the endosymbiont-derived eukaryotic organelle. The knockout of CMAL in Arabidopsis impairs the chloroplast ribosome accumulation and accordingly reduced the efficiency of mRNA translation. Interestingly, the loss of CMAL leads not only to defects in chloroplast function, but also to abnormal leaf and root development and overall plant morphology. Further investigation showed that CMAL is involved in the plant development probably by modulating auxin derived signaling pathways. This study uncovered the important role of 16S rRNA methylation mediated by CMAL in chloroplast ribosome biogenesis and plant development.
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