Evidence map›Paper›PMID 32095711›Full record

ArticleACS omega2020

Novel Fusion Protein Consisting of Metallothionein, Cellulose Binding Module, and Superfolder GFP for Lead Removal from the Water Decoction of Traditional Chinese Medicine.

Qing Xiao, Jing Han, Chang Jiang, Meng Luo, Qingyi Zhang, Zhaodong He, Juan Hu, Guozeng Wang

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  3. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qing XiaoInstitute of Drug Research, Fujian Academy of Traditional Chinese Medicine, No. 282 Wusi Road, Gulou District, Fuzhou 350003, P. R. China.
Jing HanInstitute of Drug Research, Fujian Academy of Traditional Chinese Medicine, No. 282 Wusi Road, Gulou District, Fuzhou 350003, P. R. China.
Chang JiangInstitute of Drug Research, Fujian Academy of Traditional Chinese Medicine, No. 282 Wusi Road, Gulou District, Fuzhou 350003, P. R. China.
Meng LuoCollege of Biological Science and Engineering, Fuzhou University, No. 2 Xueyuan Road, Minhou County, Fuzhou 350116, P. R. China.
Qingyi ZhangCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, No. 1 Qiuyang Road, Minhou County, Fuzhou 350122, P. R. China.
Zhaodong HeInstitute of Drug Research, Fujian Academy of Traditional Chinese Medicine, No. 282 Wusi Road, Gulou District, Fuzhou 350003, P. R. China.
Juan HuInstitute of Drug Research, Fujian Academy of Traditional Chinese Medicine, No. 282 Wusi Road, Gulou District, Fuzhou 350003, P. R. China.
Guozeng WangCollege of Biological Science and Engineering, Fuzhou University, No. 2 Xueyuan Road, Minhou County, Fuzhou 350116, P. R. China.
Fujian University of Traditional Chinese Medicine · CNFuzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many methods have been used to detect heavy metals in herbal medicines, while few are developed to remove them. In this study, a novel genetically engineered fusion protein composed of metallothionein (MT), cellulose binding module (CBM), and superfolder GFP (sfGFP) was designed to remove heavy metals. MT, a kind of cysteine-rich protein, was used to chelate heavy metals with high specific affinity. The CBM facilitated the fusion protein MT-CBM-sfGFP binding to cellulose specifically, which made the purification and immobilization in one step. The sfGFP was used to detect the fusion protein MT-CBM-sfGFP easily during the process of expression and immobilization. The MT from

Identifiers

PMID32095711
PMCPMC7034022
OpenAlexW3004786121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.