ArticleTechnical innovations & patient support in radiation oncology2019
Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer - A multicentre dose planning study.
Article in Technical innovations & patient support in radiation oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02945566 (STAR-TREC), which is not on this map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
STAR-TREC: Can we Save the Rectum by Watchful Waiting or TransAnal Surgery Following (Chemo)Radiotherapy Versus Total Mesorectal Excision for Early REctal Cancer?
Who cites it
13 citing papers in PubMed.
- Radiotherapy quality assurance for mesorectum treatment planning within the multi-center phase II STAR-TReC trial: Dutch results.Radiation oncology (London, England) · 2020Trial
- Article
- Automated VMAT planning for short-course radiotherapy in locally advanced rectal cancer.PloS one · 2025Article
- Dosimetric comparison of VMAT plans in preoperative short-course rectal radiotherapy.Scientific reports · 2024Article
- Dose tracking assessment for magnetic resonance guided adaptive radiotherapy of rectal cancers.Radiation oncology (London, England) · 2024Article
- Potential dosimetric error in the adaptive workflow of a 1.5 T MR-Linac from patient movement relative to immobilisation systems.Physical and engineering sciences in medicine · 2024Article
- Ibero-American Consensus Review and Incorporation of New Biomarkers for Clinical Practice in Colorectal Cancer.Cancers · 2023Review
- Effectiveness of bladder filling control during online MR-guided adaptive radiotherapy for rectal cancer.Radiation oncology (London, England) · 2023Article
- Assessment of Radiation-Induced Bladder and Bowel Cancer Risks after Conventionally and Hypo-Fractionated Radiotherapy for the Preoperative Management of Rectal Carcinoma.Journal of personalized medicine · 2022Article
- Effect of intrafraction adaptation on PTV margins for MRI guided online adaptive radiotherapy for rectal cancer.Radiation oncology (London, England) · 2022Article
- Can we Save the rectum by watchful waiting or TransAnal surgery following (chemo)Radiotherapy versus Total mesorectal excision for early REctal Cancer (STAR-TREC)? Protocol for the international, multicentre, rolling phase II/III partially randomized patient preference trial evaluating long-course concurrent chemoradiotherapy versus short-course radiotherapy organ preservation approaches.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Article
- Article
- Online adaptive radiotherapy compared to plan selection for rectal cancer: quantifying the benefit.Radiation oncology (London, England) · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
background and purposeOrgan preservation strategies are increasingly being explored for early rectal cancer. This requires revision of target volumes according to disease stage, as well as new guidelines for treatment planning. We conducted an international, multicentre dose planning study to develop robust planning objectives for modern radiotherapy of a novel mesorectal-only target volume, as implemented in the STAR-TReC trial (NCT02945566). MATERIALS AND
methodsThe published literature was used to establish relevant dose levels for organ at risk (OAR) plan optimisation. Ten representative patients with early rectal cancer were identified. Treatment scans had mesorectal target volumes as well as bowel cavity, bladder and femoral heads outlined, and were circulated amongst the three participating institutions. Each institution produced plans for short course (SCRT, 5 × 5 Gy) and long course (LCRT, 25 × 2 Gy) treatment, using volumetric modulated arc therapy on different dose planning systems. Optimisation objectives for OARs were established by determining dose metric objectives achievable for ≥90% of plans.
resultsSixty plans, all fulfilling target coverage criteria, were produced. The planning results and literature review suggested optimisation objectives for SCRT:
conclusionWe utilized a multicentre planning study approach to develop robust planning objectives for mesorectal radiotherapy for early rectal cancer.
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Registered trials
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