Evidence map›Paper›PMID 32095540›Full record

ArticleTechnical innovations & patient support in radiation oncology2019

A step and shoot intensity modulated technique for total body irradiation.

Lotte S Fog, Vibeke N Hansen, Flemming Kjær-Kristoffersen, Tim Egholm Berlon, Peter Meidahl Petersen, Henry Mandeville, Lena Specht

Open access · goldAbstract read
In one paragraph

Article in Technical innovations & patient support in radiation oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Evaluation of dose distributions in the overlapping regions of the modulated volumetric arcs used in total body irradiation in pediatric patients.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
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  2. Article
  3. Article
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  5. Article
  6. Review
  7. Two compound techniques for total body irradiation.Technical innovations & patient support in radiation oncology · 2022
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  8. Article
  9. Article
  10. Practice Patterns of Pediatric Total Body Irradiation Techniques: A Children's Oncology Group Survey.International journal of radiation oncology, biology, physics · 2021
    Article
  11. A customizable aluminum compensator system for total body irradiation.Journal of applied clinical medical physics · 2021
    Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lotte S FogDept. of Oncology, Rigshospitalet, University of Copenhagen, Denmark.
Vibeke N HansenJoint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Flemming Kjær-KristoffersenDept. of Oncology, Rigshospitalet, University of Copenhagen, Denmark.
Tim Egholm BerlonDept. of Oncology, Rigshospitalet, University of Copenhagen, Denmark.
Peter Meidahl PetersenDept. of Oncology, Rigshospitalet, University of Copenhagen, Denmark.
Henry MandevilleThe Royal Marsden NHS Foundation Trust, London, United Kingdom.
Lena SpechtDept. of Oncology, Rigshospitalet, University of Copenhagen, Denmark.
University of Copenhagen · DKRoyal Marsden NHS Foundation Trust · GBRigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTotal body irradiation (TBI) is a part of the conditioning regimen for bone marrow transplant.At the Royal Marsden (Sutton, UK) and Rigshospitalet (Copenhagen, Denmark), we introduced a step and shoot IMRT (SS IMRT) technique for TBI. This technique requires no equipment other than that used to deliver other external beam radiation. In this paper, we describe this technique and report on data from the two clinics. MATERIALS AND

methodsThe patients were positioned supine, supported by vacuum bag(s). The entire body of the patients were CT scanned with 5 mm slices. Multiple multi-leaf collimator (MLC) defined fields were used.In-vivo dosimetry was performed at the Royal Marsden for 113 patients.Calculated doses for 18 adult and 4 paediatric patients from Rigshospitalet were extracted.

resultsThe in-vivo data from the Royal Marsden showed that the mean TLD measured dose difference was -1.9% with a standard deviation of 4.5%.SS IMRT plans for 22 patients from Rigshospitalet resulted in mean doses to the brain, lungs and kidneys all within the range of 11.1-11.8 Gy, while the V(12 Gy) was below 5% for the brain, 2% for the lungs and 0% for the kidneys. DISCUSSION: SS IMRT is feasible for TBI and can deliver targeted doses to the organs at risk.

Indexed as

Bone marrow transplantImagingIMRTIn-vivo dosimetryTotal body irradiation

Identifiers

PMID32095540
PMCPMC7033804
OpenAlexW2951738906

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.