Evidence map›Paper›PMID 32095506›Full record

ArticleTransplantation direct2019

Kidney Donor Profile Index Is a Reliable Alternative to Liver Donor Risk Index in Quantifying Graft Quality in Liver Transplantation.

Uwe Scheuermann, Tracy Truong, Elisabeth R Seyferth, Kyle Freischlag, Qimeng Gao, John Yerxa, Brian Ezekian, Robert P Davis, Paul M Schroder, Sarah B Peskoe and 1 more

Abstract read
In one paragraph

Article in Transplantation direct, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Uwe ScheuermannDepartment of Surgery, Duke University Medical Center, Durham, NC.
Tracy TruongDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC.
Elisabeth R SeyferthDepartment of Surgery, Duke University Medical Center, Durham, NC.
Kyle FreischlagDepartment of Surgery, Duke University Medical Center, Durham, NC.
Qimeng GaoDepartment of Surgery, Duke University Medical Center, Durham, NC.
John YerxaDepartment of Surgery, Duke University Medical Center, Durham, NC.
Brian EzekianDepartment of Surgery, Duke University Medical Center, Durham, NC.
Robert P DavisDepartment of Surgery, Duke University Medical Center, Durham, NC.
Paul M SchroderDepartment of Surgery, Duke University Medical Center, Durham, NC.
Sarah B PeskoeDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC.
Andrew S BarbasDepartment of Surgery, Duke University Medical Center, Durham, NC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe most established metric for estimating graft survival from donor characteristics in liver transplantation is the liver donor risk index (LDRI). The LDRI is calculated from donor and transplant-related variables, including cold ischemic time. Because cold ischemic time is unknown at the time of organ offer, LDRI is not available for organ acceptance decisions. In contrast, the kidney donor profile index (KDPI) is derived purely from donor variables known at the time of offer and thus calculated for every deceased donor in the United States. The similarity in donor factors included in LDRI and KDPI led us to hypothesize that KDPI would reliably approximate LDRI in estimating graft survival in liver transplantation.

methodsThe United Network of Organ Sharing registry was queried for adults who underwent deceased donor liver transplantation from 2002 to 2016. The cohort was divided into quintiles of KDPI and LDRI, and graft survival was calculated according to Kaplan Meier. Hazard ratios for LDRI and KDPI were estimated from Cox proportional hazards models, and Uno's concordance statistic was compared.

resultsIn our analysis of 63 906 cases, KDPI closely approximated LDRI in estimating liver graft survival, with an equivalent concordance statistic of 0.56.

conclusionsWe conclude that KDPI can serve as a reasonable alternative to LDRI in liver acceptance decisions.

Identifiers

PMID32095506
PMCPMC7004589

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.