ArticleCurrent opinion in behavioral sciences2020
Age-related neural dedifferentiation and cognition.
Article in Current opinion in behavioral sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- A systematic review of global signal topography in aging, neuropsychiatric disorders, and cognitive task performance.Brain imaging and behavior · 2026Pooled it
- A meta-analysis of cognitive flexibility in aging: Perspective from functional network and lateralization.Human brain mapping · 2024Pooled it
- Hierarchical disruption of lateral prefrontal cortex gradients in cognitive aging.GeroScience · 2026Article
- Effects of age on memory-related category-selective connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Structure-function dynamics in healthy cognitive aging: a graph signal processing approach.Brain structure & function · 2026Article
- White-matter connectivity shapes visual and semantic representations in the aging brain.bioRxiv : the preprint server for biology · 2026Article
- Individual differences reveal distinct age-related reorganizations in spatial channels for luminance and texture processing.npj aging · 2026Article
- Age-related differences in spatial memory occur alongside reduced visual fMRI BOLD but preserved viewpoint-specific scene representations.bioRxiv : the preprint server for biology · 2026Article
- Epigenomic aberrations of histone methylation in prefrontal cortex of humans with mild cognitive impairment and Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2026Article
- Association between processing speed and segregation/integration of large-scale functional networks in middle-aged and older people living with HIV.BMC neurology · 2026Article
- The relationship between category-level neural differentiation and exploratory eye movements in healthy young and older adults.Neurobiology of aging · 2025Article
- Age Differences in False Memories Induced by Misinformation: The Role of Attentional Salience of Original Information.PsyCh journal · 2025Article
- Stage-dependent patterns of cognitive network connectivity in early psychosis.Nature communications · 2025Article
- Electrophysiological resting-state signatures link polygenic scores to general intelligence.Scientific reports · 2025Observational
- Sentence recall and neurophysiological effects of the "2-Sentence Problem" under time compression in younger and older listeners.Hearing research · 2025Article
- Temporal dedifferentiation of neural states with age during naturalistic viewing.Communications biology · 2025Article
- Top-down attention and Alzheimer's pathology affect cortical selectivity during learning, influencing episodic memory in older adults.Science advances · 2025Article
- Attending to Remember: Recent Advances in Methods and Theory.Current directions in psychological science · 2025Article
- The unity/diversity framework of executive functions: behavioral and neural evidence in older adults.GeroScience · 2025Article
- Resting state brain network segregation is associated with walking speed and working memory in older adults.NeuroImage · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
This review focuses on possible contributions of neural dedifferentiation to age-related cognitive decline. Neural dedifferentiation is held to reflect a breakdown in the functional specificity of brain regions and networks that compromises the fidelity of neural representations supporting episodic memory and related cognitive functions. The evidence for age-related dedifferentiation is robust when it is operationalized as neural selectivity for different categories of perceptual stimuli or as decreased segregation or modularity of resting-state functional brain networks. Neural dedifferentiation for perceptual categories appears to demonstrate a negative, age-invariant relationship with performance on tests of memory and fluid processing. Whether this pattern extends to network-level measures of dedifferentiation cannot currently be determined due to insufficient evidence. The existing data highlight the importance of further examination of neural dedifferentiation as a factor contributing to episodic memory and to cognitive performance more generally.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.