Evidence map›Paper›PMID 32095489›Full record

ArticleStructural dynamics (Melville, N.Y.)2020

Conformational sampling and kinetics changes across a non-Arrhenius break point in the enzyme thermolysin.

Ming Dong, Mackenzie L Lauro, Timothy J Koblish, Brian J Bahnson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Structural dynamics (Melville, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Accelerated Uptake of COACS applied materials & interfaces · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ming DongDepartment of Chemistry, North Carolina A&T State University, Greensboro, North Carolina 27411, USA.ORCID https://orcid.org/0000-0002-9121-6020
Mackenzie L LauroDepartment of Chemistry & Biochemistry, University of Delaware, Newark, Delaware 19716, USA.
Timothy J KoblishDepartment of Chemistry & Biochemistry, University of Delaware, Newark, Delaware 19716, USA.
Brian J BahnsonDepartment of Chemistry & Biochemistry, University of Delaware, Newark, Delaware 19716, USA.ORCID https://orcid.org/0000-0002-1562-8314
North Carolina Agricultural and Technical State University · US

Funding

COBRE on Membrane Protein Production and CharacterizationP30GM103519 · NIGMS · UNIVERSITY OF DELAWARE · PI LENHOFF, ABRAHAM M · 2012 to 2014
$3.3M
Structure and Interfacial Function of Platelet Activating Factor AcetylhydrolaseR01HL084366 · NHLBI · UNIVERSITY OF DELAWARE · PI BAHNSON, BRIAN J · 2007 to 2011
$1.7M
NHLBI NIH HHS R01 HL084366NIGMS NIH HHS P30 GM103519
6 · The paper itself

Abstract

Numerous studies have suggested a significant role that protein dynamics play in optimizing enzyme catalysis, and changes in conformational sampling offer a window to explore this role. Thermolysin from

Identifiers

PMID32095489
PMCPMC7021514
OpenAlexW3005648210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.