Evidence map›Paper›PMID 32095199›Full record

ArticleBiomicrofluidics2020

Enhanced sample filling and discretization in thermoplastic 2D microwell arrays using asymmetric contact angles.

S Padmanabhan, J Y Han, I Nanayankkara, K Tran, P Ho, N Mesfin, I White, D L DeVoe

Abstract read
In one paragraph

Article in Biomicrofluidics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Functional PDMS Elastomers: Bulk Composites, Surface Engineering, and Precision Fabrication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

S PadmanabhanDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, USA.ORCID 0000-0002-6149-4409
J Y HanDepartment of Mechanical Engineering, University of Maryland, College Park, Maryland 20742, USA.ORCID 0000-0003-2518-7724
I NanayankkaraDepartment of Bioengineering, University of Maryland, College Park, Maryland 20742, USA.
K TranDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, USA.
P HoDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, USA.
N MesfinDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, USA.
I WhiteDepartment of Bioengineering, University of Maryland, College Park, Maryland 20742, USA.ORCID 0000-0003-4426-9311

Funding

Enabling exosome biomarker development via digitized single vesicle analysisR01GM130923 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI DEVOE, DON L, WHITE, IAN M · 2019 to 2022
$1.7M
NIGMS NIH HHS R01 GM130923
6 · The paper itself

Abstract

Sample filling and discretization within thermoplastic 2D microwell arrays is investigated toward the development of low cost disposable microfluidics for passive sample discretization. By using a high level of contact angle asymmetry between the filling channel and microwell surfaces, a significant increase in the range of well geometries that can be successfully filled is revealed. The performance of various array designs is characterized numerically and experimentally to assess the impact of contact angle asymmetry and device geometry on sample filling and discretization, resulting in guidelines to ensure robust microwell filling and sample isolation over a wide range of well dimensions. Using the developed design rules, reliable and bubble-free sample filling and discretization is achieved in designs with critical dimensions ranging from 20

Identifiers

PMID32095199
PMCPMC7028432

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.