Evidence map›Paper›PMID 32095171›Full record

ArticleGastroenterology research2020

Histologic Lesions of Porto-Sinusoidal Vascular Disease Following Phlebotomy in Hemochromatosis.

Tony El Jabbour, Kelsey E McHugh, Deepa T Patil, Chunlai Zuo, Brandon H Koo, Sungeun Kim, Hwajeong Lee

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Tony El JabbourAnatomic Pathology, Albany Medical College, Albany, NY, USA.
Kelsey E McHughAnatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.
Deepa T PatilAnatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.
Chunlai ZuoAnatomic Pathology, Albany Medical College, Albany, NY, USA.
Brandon H KooAlbany Medical College, Albany, NY, USA.
Sungeun KimAnatomic Pathology, Albany Medical College, Albany, NY, USA.
Hwajeong LeeAnatomic Pathology, Albany Medical College, Albany, NY, USA.
Albany Medical Center Hospital · USBrigham and Women's Hospital · USCleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhlebotomy induces regression of liver fibrosis in genetic hemochromatosis. We assessed the histologic changes in pre-phlebotomy and post-phlebotomy liver biopsies from patients with

methodsA total of 51 biopsies (22 pre-phlebotomy and 29 post-phlebotomy) were reviewed, and three variables were studied: iron index indicative of the amount of accumulated iron (range 0 to 18), the combined score of vascular changes reflecting the presence of histological lesions that are described in PSVD (range 0 to 9) and the high-grade shunt vessel by calculating the proportion of portal tracts with shunt vessels, with a cutoff of 50%. Two-tailed Student's

resultsThe iron index was higher in the pre-phlebotomy compared to post-phlebotomy group (P = 0.01). Compared to the pre-phlebotomy group, the combined score was higher in the post-phlebotomy group when the cases of advanced fibrosis were excluded (P = 0.023) and remained higher when patients with risk factors for PSVD were further excluded (P = 0.034). The high-grade shunt vessel tended to be more common in the post-phlebotomy group when advanced fibrosis was excluded; however, the statistical significance was marginal (P = 0.056).

conclusionsPhlebotomy reduces hepatic iron load and induces histologic lesions of PSVD in patients with

Indexed as

FibrosisHemochromatosisLiverPhlebotomyPortal hypertensionPorto-sinusoidal vascular disease

Identifiers

PMID32095171
PMCPMC7011912
OpenAlexW3003606118

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.