Evidence map›Paper›PMID 32095094›Full record

ReviewJournal of ginseng research2020

Anti-platelet role of Korean ginseng and ginsenosides in cardiovascular diseases.

Muhammad Irfan, Minki Kim, Man Hee Rhee

Open access · goldAbstract readReview
In one paragraph

Review in Journal of ginseng research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. The application ofAnnals of translational medicine · 2025
    Review
  11. Acquired platelet disorders.Frontiers in medicine · 2025
    Review
  12. Article
  13. Natural Products in the Clinical Management of Metabolic Syndrome.Handbook of experimental pharmacology · 2025
    Review
  14. Review
  15. The beneficial potential of ginseng for menopause.Journal of ginseng research · 2024
    Review
  16. Article
  17. Article
  18. The purified extract of steamedJournal of ginseng research · 2023
    Article
  19. The Inhibitory Effects ofPreventive nutrition and food science · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Muhammad IrfanLaboratory of Veterinary Physiology and Cell Signaling, Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
Minki KimLaboratory of Veterinary Physiology and Cell Signaling, Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
Man Hee RheeLaboratory of Veterinary Physiology and Cell Signaling, Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
Kyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases prevail among modern societies and underdeveloped countries, and a high mortality rate has also been reported by the World Health Organization affecting millions of people worldwide. Hyperactive platelets are the major culprits in thrombotic disorders. A group of drugs is available to deal with such platelet-related disorders; however, sometimes, side effects and complications caused by these drugs outweigh their benefits. Ginseng and its nutraceuticals have been reported to reduce the impact of thrombotic conditions and improve cardiovascular health by antiplatelet mechanisms. This review provides (1) a comprehensive insight into the available pharmacological options from ginseng and ginsenosides (saponin and nonsaponin fractions) for platelet-originated cardiovascular disorders; (2) a discussion on the impact of specific functional groups on the modulation of platelet functions and how structural modifications among ginsenosides affect platelet activation, which may further provide a basis for drug design, optimization, and the development of ginsenoside scaffolds as pharmacological antiplatelet agents; (3) an insight into the synergistic effects of ginsenosides on platelet functions; and (4) a perspective on future research and the development of ginseng and ginsenosides as super nutraceuticals.

Indexed as

AA, arachidonic acidAC, adenylyl cyclaseADP, adenosine diphosphateAkt, protein kinase BAntiplateletaPTT, activated partial thromboplastin timeASA, acetylsalicylic acidATP, adenosine triphosphate[Ca2+]i, intracellular calcium ioncAMP, cyclic adenosine monophosphateCOX, cyclooxygenasecPLA2α, cytosolic phospholipase A2αCRP, collagen-related peptideCSF, crude saponin fractionERK, extracellular signal–regulated kinaseGinsenosidesGPVI, glycoprotein VIIC50, half maximal (50%) inhibitory concentrationIP3, inositol-1,4,5-triphosphateJNK, c-Jun N-terminal kinaseMAPK, mitogen-activated protein kinaseMKK4, mitogen-activated protein kinase kinase 4MLC, myosin light chainNutraceuticalPAF, platelet-activating factorPAR, proteinase-activated receptorPI3K, phosphatidylinositol 3-kinasePKA, protein kinase APKC, protein kinase CPKG, protein kinase GPLA2, phospholipase A2PLCγ2, phospholipase C gamma-2PPD, protopanaxadiolPPT, protopanaxatriolPT, prothrombin timeROCK, Rho-associated protein kinaseSFK, Src family kinaseStructural modificationSyk, spleen tyrosine kinaseSynergismTS, total saponinTxA2, thromboxane A2TxAS, thromboxane-A synthaseTxB2, thromboxane B2TxR, thromboxane receptorVASP, vasodilator-stimulated phosphoproteinvWF, von Willebrand factor

Identifiers

PMID32095094
PMCPMC7033355
OpenAlexW2946752329

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.