ArticleNature biotechnology2020
Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes.
Abstract readLetterComment
In one paragraph
Article in Nature biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Confounders of lncRNA screens: sources, consequences and possible solutions.Nature methods · 2026Article
- Region-Level Design and Analysis of CRISPR Perturbation Screens with FRACTEL.bioRxiv : the preprint server for biology · 2026Article
- Long noncoding RNA regulation of immunity.Nature immunology · 2026Review
- Computational identification and validation of non-coding rna biomarkers in gastrointestinal cancer.Functional & integrative genomics · 2025Review
- Roles of long non-coding RNAs in oesophageal cancer pathogenesis.International journal of experimental pathology · 2025Review
- The role of long non-coding RNAs and circular RNAs in immune evasion of influenza A virus: recent advances.Frontiers in cellular and infection microbiology · 2025Review
- Reevaluation by the CRISPR/Cas9 knockout approach revealed that multiple pluripotency-associated lncRNAs are dispensable for pluripotency maintenance while Snora73a/b is essential for pluripotency exit.Science China. Life sciences · 2024Article
- Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx.Nature methods · 2024Article
- Approaches to probe and perturb long noncoding RNA functions in diseases.Current opinion in genetics & development · 2024Review
- Are non-protein coding RNAs junk or treasure?: An attempt to explain and reconcile opposing viewpoints of whether the human genome is mostly transcribed into non-functional or functional RNAs.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Article
- CRISPRlnc: a machine learning method for lncRNA-specific single-guide RNA design of CRISPR/Cas9 system.Briefings in bioinformatics · 2024Article
- Long non-coding RNAs: definitions, functions, challenges and recommendations.Nature reviews. Molecular cell biology · 2023Review
- Long Non-coding RNAs and CRISPR-Cas Edition in Tumorigenesis.Advances in experimental medicine and biology · 2023Article
- Epigenetic reprogramming in cancer: From diagnosis to treatment.Frontiers in cell and developmental biology · 2023Review
- Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs.Frontiers in endocrinology · 2023Review
- Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilities.Cell genomics · 2022Article
- Gene editing and its applications in biomedicine.Science China. Life sciences · 2022Review
- A new era in functional genomics screens.Nature reviews. Genetics · 2022Review
- Identification and Functional Analysis of lncRNA by CRISPR/Cas9 During the Cotton Response to Sap-Sucking Insect Infestation.Frontiers in plant science · 2022Article
- CRISPR-Based Approaches for the High-Throughput Characterization of Long Non-Coding RNAs.Non-coding RNA · 2021Review
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Authors and funding
5 authors.
Max A HorlbeckDepartment of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3875-871X
S John LiuDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9459-4393
Daniel A LimDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Jonathan S WeissmanDepartment of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA. Jonathan.Weissman@ucsf.edu.ORCID http://orcid.org/0000-0003-2445-670X
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MLncRNA mechanisms in cancerR35CA209919 · NCI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2016 to 2022
$6.4MBay Area Cancer Target Discovery and Development NetworkU01CA168370 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCCORMICK, FRANK PATRICK, MCMANUS, MICHAEL T · 2012 to 2016
$3.9MHarnessing CRISPR for Targeted and Inducible Epigenomic ReprogrammingR01DA036858 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIM, WENDELL A, QI, LEI STANLEY · 2013 to 2017
$2.9MLong noncoding RNA regulation of neural stem cellsR01NS091544 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIM, DANIEL A · 2016 to 2020
$1.7MRegulation of neurogenesis by the novel long non-coding RNA PnkyF30NS092319 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIU, SIYUAN JOHN · 2015 to 2016
$70kHoward Hughes Medical InstituteNCI NIH HHS R35 CA209919NCI NIH HHS U01 CA168370NIDA NIH HHS R01 DA036858NIGMS NIH HHS T32 GM007618NINDS NIH HHS F30 NS092319NINDS NIH HHS R01 NS091544
Abstract
PubMed holds no abstract for this paper.
Indexed as
RNA, Long NoncodingClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsHumansRNA, Guide, CRISPR-Cas SystemsRNA, Guide, CRISPR-Cas SystemsRNA, Long Noncoding
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.