ArticleMolecular psychiatry2021
Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure.
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In one paragraph
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
8.9field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury.Brain : a journal of neurology · 2025Pooled it
- Peripheral Blood and Salivary Biomarkers of Blood-Brain Barrier Permeability and Neuronal Damage: Clinical and Applied Concepts.Frontiers in neurology · 2020Pooled it
- Post-traumatic stress disorder: pathogenesis, epidemiological characteristics, animal models, and potential therapeutic strategies.Military Medical Research · 2026Review
- Integrated Blood Biomarker and Neurobehavioural Signatures of Latent Neuroinjury in Experienced Military Breachers Exposed to Repetitive Low-Intensity Blast.International journal of molecular sciences · 2026Article
- Boldine treatment prevents chronic cognitive impairment and exaggerated fear learning in rats exposed to repetitive low-level blast injury.Frontiers in cellular neuroscience · 2026Article
- Tau-PET imaging and blood biomarkers reveal early tauopathy in special operations forces exposed to repetitive blast.Brain communications · 2026Article
- Tau biomarkers in Special Operations Forces with repeated blast exposure: a cross-sectional study.Brain communications · 2026Article
- Sex-dependent blood-brain barrier alterations following repeated mild blast traumatic brain injury at varying inter-injury intervals.Experimental neurology · 2025Article
- Traumatic Brain Injury and Suicidal Thoughts and Behaviors among Post-9/11 Veterans: Investigating Longitudinal Change and Interactions with Mental Health.Psychiatry research · 2025Article
- Assessment model of blast injury: A narrative review.iScience · 2025Review
- Neuroinflammatory mechanisms may help identify candidate biomarkers in chronic traumatic encephalopathy (CTE).Free neuropathology · 2025Review
- Serotonin 5-HT2A receptor expression is chronically decreased in the anterior cerebral cortex of male rats following repetitive low-level blast exposure.Frontiers in neurology · 2025Article
- Chronic Neurobehavioral and Neuropathological Consequences of Repeated Blast Exposure in P301S Transgenic Tau Rats.Neurotrauma reports · 2025Article
- Minocycline partially reverses established PTSD-related behavioral traits in rats exposed to repetitive low-level blast injury.Frontiers in neurology · 2025Article
- From imaging to intervention: emerging potential of PET biomarkers to shape therapeutic strategies for TBI-induced neurodegeneration.Frontiers in neurology · 2025Review
- Modeling Highly Repetitive Low-level Blast Exposure in Mice.Journal of visualized experiments : JoVE · 2024Article
- The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma.International journal of molecular sciences · 2024Review
- Fecal microbiota transplantation alleviates cognitive impairment by improving gut microbiome composition and barrier function in male rats of traumatic brain injury following gas explosion.Frontiers in microbiology · 2024Article
- A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles.Brain communications · 2024Review
- Recent insights from non-mammalian models of brain injuries: an emerging literature.Frontiers in neurology · 2024Review
Corrections and comments
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Authors and funding
32 authors at 14 institutions in 4 countries.
Dara L Dickstein *Department of Pathology, Uniformed Services University of Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD, 20814, USA.
Rita De Gasperi *Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA.
Miguel A Gama SosaResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA.
Georgina Perez-GarciaResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA.
Jennifer A ShortDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA.
Heidi SosaResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA.
Gissel M PerezResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA.
Anna E TschiffelyDepartment of Neurotrauma, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.
Kristen Dams-O'ConnorDepartment of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA.
Mariel Y PullmanDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA.
Karin KnesaurekDepartment of Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Andrew KnutsenCenter for Neuroscience and Regenerative Medicine, Bethesda, MD, 20814, USA.
Dzung L PhamCenter for Neuroscience and Regenerative Medicine, Bethesda, MD, 20814, USA.
Lale SoleimaniDepartment of Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Barry D JordanBurke Rehabilitation and Research, 785 Mamaroneck Avenue, White Plains, NY, 10605, USA.
Wayne A GordonDepartment of Rehabilitation and Physical Medicine, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA.
Bradley N DelmanDepartment of Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Gleb ShumyatskyDepartment of Genetics, Rutgers University, Piscataway, NJ, 08854, USA.
Pashtun-Poh ShahimCenter for Neuroscience and Regenerative Medicine, Bethesda, MD, 20814, USA.
Steven T DeKoskyDepartment of Neurology, University of Florida, Gainesville, FL, 32611, USA.
James R StoneDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VI, 2903, USA.
Elaine PeskindVA Northwest Network Mental Illness Research, Education, and Clinical Center, Seattle, WA, 98195, USA.
Kaj BlennowInstitute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, S-431 80, Mölndal, Sweden.
Henrik ZetterbergInstitute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, S-431 80, Mölndal, Sweden.
Steven A ChanceNuffield Department of Clinical Neurosciences, University of Oxford, Neuropathology, West Wing, Level 1, Oxford, OX3 9DU, UK.
Mario TorsoNuffield Department of Clinical Neurosciences, University of Oxford, Neuropathology, West Wing, Level 1, Oxford, OX3 9DU, UK.
Lale KostakogluDepartment of Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Mary SanoResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA.
Patrick R HofMount Sinai Alzheimer's Disease Research Center and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Stephen T AhlersDepartment of Neurotrauma, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.
Sam GandyResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA. samuel.gandy@mssm.edu.
Gregory A ElderDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA. gregory.elder@va.gov.
Icahn School of Medicine at Mount Sinai · USJames J. Peters VA Medical Center · USCenter for Neuroscience and Regenerative Medicine · USNaval Medical Research Command · USSahlgrenska University Hospital · SEUniversity of Oxford · GBAllen Institute for Brain Science · USBurke Rehabilitation Hospital · USNational Institute of Neurological Disorders and Stroke · USRutgers, The State University of New Jersey · USUniformed Services University of the Health Sciences · USUniversity of Florida · USUniversity of Virginia · USUniversity of Washington · US
Funding
Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HILLEL GROSSMAN · 2020 to 2026
$31.0MNeuropathology of CTE and Delayed Effects of TBI: Toward In-Vivo DiagnosticsU01NS086625 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN · 2014 to 2017
$6.1MActivity-Dependent Cellular and Molecular Events Regulating MemoryR01MH107555 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI SHUMYATSKY, GLEB P · 2016 to 2020
$1.9MThe role of GRP and GRPergic circuitry in fear memoryR01MH080328 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI SHUMYATSKY, GLEB P · 2009 to 2010
$1.2MComprehensive Investigation of the Clinical Course of Traumatic Brain InjuryK01HD074651 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN · 2014 to 2018
$536kMild TBI and Biomarkers of NeurodegenerationI01RX003087 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI PESKIND, ELAINE R. · 2019 to 2024
–Expression of ΔFosB as a Therapy for Blast-Induced PTSDI21RX002069 · VA · JAMES J PETERS VA MEDICAL CENTER · PI GAMA SOSA, MIGUEL A · 2016 to 2017
–The Structural and Molecular Basis of Blast-Induced Vascular InjuryI01BX004067 · VA · JAMES J PETERS VA MEDICAL CENTER · PI ELDER, GREGORY A. · 2019 to 2022
–MOLECULAR CELL BIOLOGY OF ALZHEIMER AMYLOIDOGENESISR01AG011508 · NIA · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI GANDY, SAMUEL E · 1992 to 1994
–MOLECULAR CELL BIOLOGY OF ALZHEIMER AMYLOIDOGENESISR55AG011508 · NIA · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI GANDY, SAMUEL E · 1995 to 1995
–FGF1 Treatment of Cerebral Vascular Degenerations in blast mTBII21RX002876 · VA · JAMES J PETERS VA MEDICAL CENTER · PI GAMA SOSA, MIGUEL A · 2018 to 2020
–Rehab Therapy Adjunct with a Neurogenic, Mnemoactive, A-Beta-Lowering CompoundI01RX000684 · VA · JAMES J PETERS VA MEDICAL CENTER · PI GANDY, SAMUEL E. · 2014 to 2017
–BLRD VA I01 BX004067NIA NIH HHS P30 AG066514NICHD NIH HHS K01 HD074651NIMH NIH HHS R01 MH080328NIMH NIH HHS R01 MH107555NINDS NIH HHS U01 NS086625RRD VA I01 RX000684RRD VA I01 RX000996RRD VA I01 RX002333RRD VA I01 RX002660RRD VA I01 RX003087RRD VA I21 RX002069RRD VA I21 RX002876
Abstract
Traumatic brain injury (TBI) is a risk factor for the later development of neurodegenerative diseases that may have various underlying pathologies. Chronic traumatic encephalopathy (CTE) in particular is associated with repetitive mild TBI (mTBI) and is characterized pathologically by aggregation of hyperphosphorylated tau into neurofibrillary tangles (NFTs). CTE may be suspected when behavior, cognition, and/or memory deteriorate following repetitive mTBI. Exposure to blast overpressure from improvised explosive devices (IEDs) has been implicated as a potential antecedent for CTE amongst Iraq and Afghanistan Warfighters. In this study, we identified biomarker signatures in rats exposed to repetitive low-level blast that develop chronic anxiety-related traits and in human veterans exposed to IED blasts in theater with behavioral, cognitive, and/or memory complaints. Rats exposed to repetitive low-level blasts accumulated abnormal hyperphosphorylated tau in neuronal perikarya and perivascular astroglial processes. Using positron emission tomography (PET) and the [
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Chronic Traumatic EncephalopathyTauopathiesAnimalsBiomarkersBrainHumansRatsSyndromeBiomarkers
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