Evidence map›Paper›PMID 32094464›Full record

ArticleLeukemia2020

Decreased cell stiffness enhances leukemia development and progression.

Linping Hu, Fang Ni, Xinyi Wang, Meredith E Fay, Katherine M Young, Wilbur A Lam, Todd A Sulchek, Cheng-Kui Qu

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Manipulation and Mechanical Deformation of Leukemia Cells by High-Frequency Ultrasound Single Beam.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022
    Article
  8. Article
  9. Biomechanical cues as master regulators of hematopoietic stem cell fate.Cellular and molecular life sciences : CMLS · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Linping Hu *Department of Pediatrics, Division of Hematology and Oncology, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, 30322, USA.
Fang Ni *Department of Pediatrics, Division of Hematology and Oncology, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, 30322, USA.
Xinyi WangDepartment of Pediatrics, Division of Hematology and Oncology, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, 30322, USA.
Meredith E FayDepartment of Pediatrics, Division of Hematology and Oncology, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, 30322, USA.
Katherine M YoungThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Wilbur A LamDepartment of Pediatrics, Division of Hematology and Oncology, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, 30322, USA.ORCID http://orcid.org/0000-0002-0325-7990
Todd A SulchekThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Cheng-Kui QuDepartment of Pediatrics, Division of Hematology and Oncology, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, 30322, USA. cheng-kui.qu@emory.edu.ORCID http://orcid.org/0000-0002-4256-8652

Funding

Germline mutations of PTPN11 (SHP2) in the stem cell microenvironmentR01HL130995 · NHLBI · EMORY UNIVERSITY · PI QU, CHENG-KUI · 2016 to 2024
$3.3M
Metabolic regulation of hematopoietic stem cellsR01DK092722 · NIDDK · EMORY UNIVERSITY · PI QU, CHENG-KUI · 2011 to 2019
$2.5M
NHLBI NIH HHS R01 HL130995NIDDK NIH HHS R01 DK092722U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL130995U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK092722
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell ShapeAnimalsDisease ProgressionHumansLeukemiaMiceMice, KnockoutProtein Tyrosine Phosphatases, Non-ReceptorProtein Tyrosine Phosphatases, Non-ReceptorPtpn21 protein, mouse

Identifiers

PMID32094464
PMCPMC9128390

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.