Evidence map›Paper›PMID 32094439›Full record

ArticleScientific reports2020

A representative metalloprotease induces PGE

Mariana N Viana, Elbio Leiguez, José M Gutiérrez, Alexandra Rucavado, Regina P Markus, Marina Marçola, Catarina Teixeira, Cristina M Fernandes

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mariana N VianaPharmacology Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Elbio LeiguezPharmacology Laboratory, Butantan Institute, São Paulo, SP, Brazil.
José M GutiérrezClodomiro Picado Institute, School of Microbiology, University of Costa Rica, San José, Costa Rica.
Alexandra RucavadoClodomiro Picado Institute, School of Microbiology, University of Costa Rica, San José, Costa Rica.
Regina P MarkusDepartment of Physiology, Institute of Biosciences, São Paulo University, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0003-4606-6120
Marina MarçolaDepartment of Physiology, Institute of Biosciences, São Paulo University, São Paulo, SP, Brazil.
Catarina Teixeira *Pharmacology Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Cristina M Fernandes *Pharmacology Laboratory, Butantan Institute, São Paulo, SP, Brazil. cristina.fernandes@butantan.gov.br.ORCID http://orcid.org/0000-0001-8054-0362
Instituto Butantan · BRUniversidad de Costa Rica · CRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory joint conditions are characterized by synovial inflammation, which involves activation of fibroblast-like synoviocytes (FLSs) and production of inflammatory mediators and matrix metalloproteases (MMPs) in joints. This study showed that the snake venom metalloprotease (SVMP) BaP1 activates FLSs to produce PGE

Indexed as

Signal TransductionAnimalsCyclooxygenase 2DinoprostoneFibroblastsGene Expression RegulationInflammationInterleukin-1betaMaleMetalloendopeptidasesNF-kappa BRatsRats, WistarReceptors, Prostaglandin E, EP4 SubtypeRheumatic DiseasesSynovial FluidBaP1 metalloproteinaseCyclooxygenase 2DinoprostoneIL1B protein, ratInterleukin-1betaMetalloendopeptidasesNF-kappa BPtger4 protein, ratPtgs2 protein, ratReceptors, Prostaglandin E, EP4 Subtype

Identifiers

PMID32094439
PMCPMC7039882
OpenAlexW3006979872

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.