Evidence map›Paper›PMID 32094405›Full record

ArticleScientific reports2020

Capture and light-induced release of antibiotics by an azo dye polymer.

Stephen Atkins, Alysa Chueh, Taylor Barwell, Jean-Michel Nunzi, Laurent Seroude

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Stephen AtkinsDepartment of Biology, Queen's University, Kingston, ON, K7L-3N6, Canada.
Alysa ChuehDepartment of Chemistry, Queen's University, Kingston, ON, K7L-3N6, Canada.
Taylor BarwellDepartment of Biology, Queen's University, Kingston, ON, K7L-3N6, Canada.
Jean-Michel NunziDepartment of Chemistry, Queen's University, Kingston, ON, K7L-3N6, Canada. nunzijm@queensu.ca.
Laurent SeroudeDepartment of Biology, Queen's University, Kingston, ON, K7L-3N6, Canada. seroudel@queensu.ca.
Queen's University · CA

Funding

Canada Research Chairs 229043Natural Sciences and Engineering Research Council of Canada RGPIN-2015-05485
6 · The paper itself

Abstract

The isomerisation of azo dyes can induce conformational changes which have potential applications in medicine and environmental protection. We developed an agar diffusion assay to test the capture and release of biologically active molecules from an azo electro-optic polymer, Poly (Disperse Red 1 methacrylate) (DR1/PMMA). The assay monitors the growth of bacteria placed in soft agar under a glass coverslip. Antibiotics can then be applied on the coverslip resulting in the clearance of the area under the coverslip due to growth inhibition. This assay demonstrates that DR1/PMMA is able to capture either tetracycline or ampicillin and the relative amount of DR1/PMMA required for capture was determined. Finally, the active antibiotics can be released from DR1/PMMA by exposure to green laser light. Exposure to white light from a torch or to heat does not release the antibiotic.

Indexed as

Drug Delivery SystemsLightAgarAmpicillinAnti-Bacterial AgentsAzo CompoundsColoring AgentsDiffusionNanomedicinePhotobiologyPolymersTetracyclineAgarAmpicillinAnti-Bacterial AgentsAzo CompoundsColoring AgentsDisperse Red 1PolymersTetracycline

Identifiers

PMID32094405
PMCPMC7039927
OpenAlexW2975369442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.