ArticleScientific reports2020
Ramped pulse shapes are more efficient for cochlear implant stimulation in an animal model.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Power-efficient ramped stimulation in a fully implantable cochlear implant.Scientific reports · 2025Article
- Electrical equivalent circuit for analyzing the effect of signal shape on power distribution in cochlear implant electrodes and surrounding tissue.Scientific reports · 2025Article
- What is the best pulse shape for pacing purposes?Frontiers in physiology · 2025Article
- Preservation of vision by transpalpebral electrical stimulation in mice with inherited retinal degeneration.Frontiers in cell and developmental biology · 2024Article
- A Virtual Inner Ear Model Selects Ramped Pulse Shapes for Vestibular Afferent Stimulation.Bioengineering (Basel, Switzerland) · 2023Article
- Anodic Polarity Minimizes Facial Nerve Stimulation as a Side Effect of Cochlear Implantation.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- What Is the Benefit of Ramped Pulse Shapes for Activating Auditory Cortex Neurons? An Electrophysiological Study in an Animal Model of Cochlear Implant.Brain sciences · 2023Article
- Comparison of response properties of the electrically stimulated auditory nerve reported in human listeners and in animal models.Hearing research · 2022Review
- A fully implantable wireless bidirectional neuromodulation system for mice.Biosensors & bioelectronics · 2022Article
- Estimating health of the implanted cochlea using psychophysical strength-duration functions and electrode configuration.Hearing research · 2022Article
- Direct modulation of microglial function by electrical field.Frontiers in cell and developmental biology · 2022Article
- Effect of the Relative Timing between Same-Polarity Pulses on Thresholds and Loudness in Cochlear Implant Users.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- The Perception of Ramped Pulse Shapes in Cochlear Implant Users.Trends in hearingArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In all commercial cochlear implant (CI) devices, the electric stimulation is performed with a rectangular pulse that generally has two phases of opposite polarity. To date, developing new stimulation strategies has relied on the efficacy of this shape. Here, we investigate the potential of a novel stimulation paradigm that uses biophysically-inspired electrical ramped pulses. Using electrically-evoked auditory brainstem response (eABR) recordings in mice, we found that less charge, but higher current level amplitude, is needed to evoke responses with ramped shapes that are similar in amplitude to responses obtained with rectangular shapes. The most charge-efficient pulse shape had a rising ramp over both phases, supporting findings from previous in vitro studies. This was also true for longer phase durations. Our study presents the first physiological data on CI-stimulation with ramped pulse shapes. By reducing charge consumption ramped pulses have the potential to produce more battery-efficient CIs and may open new perspectives for designing other efficient neural implants in the future.
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