Evidence map›Paper›PMID 32094226›Full record

ArticleThe Journal of biological chemistry2020

Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages.

Ardeshir Ariana, Norah A Alturki, Stephanie Hajjar, Deborah J Stumpo, Christopher Tiedje, Emad S Alnemri, Matthias Gaestel, Perry J Blackshear, Subash Sad

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Necroptosis in obesity: a complex cell death event.Apoptosis : an international journal on programmed cell death · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Roles of RIPK3 in necroptosis, cell signaling, and disease.Experimental & molecular medicine · 2022
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Ardeshir ArianaDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.ORCID 0000-0003-2206-9829
Norah A AlturkiDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Stephanie HajjarDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Deborah J StumpoSignal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Christopher TiedjeDepartment of Cellular and Molecular Medicine, University of Copenhagen, The Maersk Tower, 7.3, Blegdamsvej 3B, Copenhagen DK-2200, Denmark.
Emad S AlnemriThomas Jefferson University, Department of Biochemistry and Molecular Biology, Philadelphia, Pennsylvania 19107.
Matthias GaestelInstitute of Cell Biochemistry, Hannover Medical School, Germany, 30623.ORCID 0000-0002-4944-4652
Perry J BlackshearSignal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Subash SadDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada subash.sad@uottawa.ca.
University of Ottawa · CANational Institute of Environmental Health Sciences · USMedizinische Hochschule Hannover · DEThomas Jefferson University · USUniversity of Copenhagen · DK

Funding

TTP and related proteins in the regulation of gene expressionZIAES090080 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BLACKSHEAR, PERRY J · 2009 to 2025
$52.6M
CIHR 375862
6 · The paper itself

Abstract

The necrosome is a protein complex required for signaling in cells that results in necroptosis, which is also dependent on tumor necrosis factor receptor (TNF-R) signaling. TNFα promotes necroptosis, and its expression is facilitated by mitogen-activated protein (MAP) kinase-activated protein kinase 2 (MK2) but is inhibited by the RNA-binding protein tristetraprolin (TTP, encoded by the

Indexed as

NecroptosisSignal TransductionAdaptor Proteins, Vesicular TransportAmino Acid Chloromethyl KetonesAnimalsCaspase 8Cells, CulturedCell SurvivalIntracellular Signaling Peptides and ProteinsJNK Mitogen-Activated Protein KinasesLipopolysaccharidesMacrophagesMAP-Kinase-Activated Kinase 2MiceMice, Inbred C57BLMice, KnockoutAdaptor Proteins, Vesicular TransportAmino Acid Chloromethyl Ketonesbenzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneCaspase 8Intracellular Signaling Peptides and ProteinsJNK Mitogen-Activated Protein KinasesLipopolysaccharidesMAP-Kinase-Activated Kinase 2Myeloid Differentiation Factor 88p38 Mitogen-Activated Protein KinasesProtein Serine-Threonine KinasesTicam1 protein, mouseToll-Like Receptor 4TristetraprolinTumor Necrosis Factor-alphacell deathcytokineinflammationnecrosisnecrosomenecrotic deathToll-like receptor 4 (TLR4)tristetraprolinZFP36 ring finger protein (ZFP36)

Identifiers

PMID32094226
PMCPMC7135981
OpenAlexW3008129052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.