Evidence map›Paper›PMID 32094134›Full record

ArticleAntimicrobial agents and chemotherapy2020

Novel Endochin-Like Quinolones Exhibit Potent

Donelly A van Schalkwyk, Michael K Riscoe, Sovitj Pou, Rolf W Winter, Aaron Nilsen, Maëlle Duffey, Robert W Moon, Colin J Sutherland

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Targeting Mitochondrial Function inInternational journal of molecular sciences · 2025
    Review
  3. Review
  4. Article
  5. Synthesis of Deuterated Endochin-Like Quinolones.Journal of labelled compounds & radiopharmaceuticals · 2024
    Article
  6. Review
  7. Review
  8. Treatment of Human Babesiosis: Then and Now.Pathogens (Basel, Switzerland) · 2021
    Review
  9. Effective Therapy Targeting CytochromeAntimicrobial agents and chemotherapy · 2021
    Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Donelly A van SchalkwykDepartment of Infection Biology, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Michael K RiscoeVeterans Affairs Medical Center, Portland, Oregon, USA.
Sovitj PouVeterans Affairs Medical Center, Portland, Oregon, USA.
Rolf W WinterVeterans Affairs Medical Center, Portland, Oregon, USA.
Aaron NilsenVeterans Affairs Medical Center, Portland, Oregon, USA.
Maëlle DuffeyMedicines for Malaria Venture, Geneva, Switzerland.
Robert W MoonDepartment of Infection Biology, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Colin J SutherlandDepartment of Infection Biology, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom colin.sutherland@lshtm.ac.uk.ORCID 0000-0003-1592-6407
London School of Hygiene & Tropical Medicine · GBPortland VA Medical Center · USMedicines for Malaria Venture · CHOregon Health & Science University · US

Funding

Optimizing ELQs for Treatment and Prevention of MalariaR01AI100569 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Michael Kevin RISCOE · 2014 to 2026
$8.0M
Development of a Sustained Release Injectable Formulation for Long-Term Delivery of ELQsR01AI141412 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI RISCOE, MICHAEL KEVIN · 2019 to 2022
$3.2M
Pharmachin Optimization and TestingI01BX003312 · VA · PORTLAND VA MEDICAL CENTER · PI RISCOE, MICHAEL KEVIN · 2016 to 2025
–
BLRD VA I01 BX001421BLRD VA I01 BX003312BLRD VA IK6 BX004857BLRD VA IS1 BX003568Medical Research Council MR/M021157/1Medical Research Council MR/T016124/1NIAID NIH HHS R01 AI100569NIAID NIH HHS R01 AI141412
6 · The paper itself

Abstract

Quinolones, such as the antimalarial atovaquone, are inhibitors of the malarial mitochondrial cytochrome

Indexed as

AnimalsAntimalarialsAtovaquoneDrug InteractionsDrug SynergismMicrobial Sensitivity TestsPlasmodium falciparumPlasmodium knowlesiProguanilQuinolones6-Chloro-7-methoxy-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-oneAntimalarialsAtovaquoneProguanilQuinolonesantimalarial chemotherapydrug susceptibilityin vitroisobologramsPlasmodium falciparumPlasmodium knowlesi

Identifiers

PMID32094134
PMCPMC7179610
OpenAlexW3007726990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.