Evidence map›Paper›PMID 32094114›Full record

ArticleDevelopment (Cambridge, England)2020

Expression of E93 provides an instructive cue to control dynamic enhancer activity and chromatin accessibility during development.

Spencer L Nystrom, Matthew J Niederhuber, Daniel J McKay

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Genomic and insulin-mediated control of metabolic homeostasis by the mosquito ecdysone-induced gene E93.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. 20E-inducedProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. E93 controls adult differentiation by repressingProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Chronologically inappropriate morphogenesis (Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Reduction of embryonicProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
  14. Knockdown ofBiology · 2022
    Article
  15. Opportunistic binding of EcR to open chromatin drives tissue-specific developmental responses.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Article
  18. Article
  19. The ecdysone-induced protein 93 is a key factor regulating gonadotrophic cycles in the adult female mosquitoProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Spencer L NystromCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0003-1000-1579
Matthew J NiederhuberCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-5916-8025
Daniel J McKayDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA dmckay1@email.unc.edu.ORCID 0000-0001-8226-0604

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
Genetic and epigenetic mechanisms of developmental gene regulationR35GM128851 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay · 2018 to 2026
$3.9M
NIGMS NIH HHS R35 GM128851NIGMS NIH HHS T32 GM007092NIH HHS P40 OD018537
6 · The paper itself

Abstract

How temporal cues combine with spatial inputs to control gene expression during development is poorly understood. Here, we test the hypothesis that the

Indexed as

AnimalsAnimals, Genetically ModifiedChromatinChromatin Assembly and DisassemblyDrosophilaDrosophila ProteinsEmbryonic DevelopmentEmbryo, NonmammalianEnhancer Elements, GeneticGene Expression Regulation, DevelopmentalMetamorphosis, BiologicalProtein BindingTranscription FactorsWings, AnimalChromatinDrosophila ProteinsEip93F protein, DrosophilaTranscription FactorsChromatin accessibilityDrosophilaEcdysoneEnhancerGene regulationTemporal transcription factor

Identifiers

PMID32094114
PMCPMC7097197

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.