ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2020
Brain structure and symptom dimensions in borderline personality disorder.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Hemispheric asymmetries in borderline personality disorder: a systematic review.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- Prevalence of Eating Disorders in People With Borderline Personality Disorder: A Systematic Review and Meta-Analysis.Clinical psychology & psychotherapyPooled it
- Early structural brain abnormalities in borderline personality disorder.Psychological medicine · 2025Article
- Neurobiological correlates of personality dimensions in borderline personality disorder using graph analysis of functional connectivity.Scientific reports · 2025Article
- Neuroanatomical and functional correlates in borderline personality disorder: A narrative review.Ibrain · 2025Review
- Impulsivity in ADHD and Borderline Personality Disorder: A Systematic Review of Gray and White Matter Variations.Journal of clinical medicine · 2024Review
- Prefrontal cortex activation under stress as a function of borderline personality disorder in female adolescents engaging in non-suicidal self-injury.BJPsych open · 2024Article
- Can we rewire criminal mind via non-invasive brain stimulation of prefrontal cortex? Insights from clinical, forensic and social cognition studies.Current psychology (New Brunswick, N.J.) · 2022Article
- Narcissistic Traits and Executive Functions.Frontiers in psychology · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBorderline personality disorder (BPD) presents with symptoms across different domains, whose neurobiology is poorly understood.
methodsWe applied voxel-based morphometry on high-resolution magnetic resonance imaging scans of 19 female BPD patients and 50 matched female controls.
resultsGroup comparison showed bilateral orbitofrontal gray matter loss in patients, but no significant changes in the hippocampus. Voxel-wise correlation of gray matter with symptom severity scores from the Borderline Symptom List (BSL-95) showed overall negative correlation in bilateral prefrontal, right inferior temporal/fusiform and occipital cortices, and left thalamus. Significant (negative) correlations with BSL-95 subscores within the patient cohort linked autoaggression to left lateral prefrontal and insular cortices, right inferior temporal/temporal pole, and right orbital cortex; dysthymia/dysphoria to right orbitofrontal cortex; self-perception to left postcentral, bilateral inferior/middle temporal, right orbitofrontal, and occipital cortices. Schema therapy-based Young Schema Questionnaire (YSQ-S2) scores of early maladaptive schemas on emotional deprivation were linked to left medial temporal lobe gray matter reductions.
conclusionsOur results confirm orbitofrontal structural deficits in BPD, while providing a framework and preliminary findings on identifying structural correlates of symptom dimensions in BPD, especially with dorsolateral and orbitofrontal cortices.
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