SynthesisEuropean psychiatry : the journal of the Association of European Psychiatrists2020
Initial and relapse prodromes in adult patients with episodes of bipolar disorder: A systematic review.
Synthesis in European psychiatry : the journal of the Association of European Psychiatrists, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychedelic-induced hypomania and mania: a systematic review and meta-analysis.Molecular psychiatry · 2026Pooled it
- Fatigue-associated gut bacteria in Japanese healthy adults characterized by metagenomic analysis.Scientific reports · 2026Article
- Sleep fluctuations precede self-reported mood changes in bipolar disorder: results from the BipoSense study.International journal of bipolar disorders · 2026Article
- Psychiatric antecedents in young patients with first episode psychosis: what relevance for clinical outcomes?European archives of psychiatry and clinical neuroscience · 2025Article
- Day-to-day variability in sleep and activity predict the onset of a hypomanic episode in patients with bipolar disorder.Journal of affective disorders · 2025Observational
- Antecedents to first episode psychosis and mania: Comparing the initial prodromes of schizophrenia and bipolar disorder in a retrospective population cohort.Journal of affective disorders · 2023Article
- Exploring Digital Biomarkers of Illness Activity in Mood Episodes: Hypotheses Generating and Model Development Study.JMIR mHealth and uHealth · 2023Observational
- Opportunities for digital health technology: identifying unmet needs for bipolar misdiagnosis and depression care management.Frontiers in digital health · 2023Article
- Risks and benefits of psilocybin use in people with bipolar disorder: An international web-based survey on experiences of 'magic mushroom' consumption.Journal of psychopharmacology (Oxford, England) · 2023Article
- Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood.Acta psychiatrica Scandinavica · 2022Article
- Recommendations for the care of patients with bipolar disorder during the COVID-19 pandemic.Journal of affective disorders · 2021Review
- Article
- The Assessment of Awareness of Early Warning Signs of Bipolar Disorder Recurrence Among Patients and Their Main Caregivers in Jordan.SAGE open nursingArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDistinguishing prodromes of bipolar disorder (BD) specific to children/adolescents, adults, and elderly patients is essential. The primary objective of this systematic review was to determine initial and relapse prodromes identifying adult patients with BD.
methodsPubMed, PsycINFO, and Web of Science databases were searched using a predetermined strategy. A controlled process of study selection and data extraction was performed.
resultsThe 22 articles selected included 1,809 adult patients with BD. Initial prodromes cited most frequently in these studies showed low specificity. Among relapse prodromes cited most frequently, more talkative than usual, increased energy/more goal-directed behavior, thoughts start to race, increased self-esteem, strong interest in sex, increase in activity, and spending too much were identified exclusively before a manic/hypomanic episode, while loss of interest and hypersomnia were detected only before a depressive episode. Initial prodromal phases lasted longer than prodromal relapse phases. In the selected studies, the most used prodrome identification procedure was the clinical interview.
conclusionsFor adult patients with BD, initial and relapse prodromes of manic, hypomanic, and depressive episodes were identified. It is proposed that the most frequent prodromes found in this review be incorporated into a smartphone app that monitors the functioning of people at risk of BD and patients who have already been diagnosed. Data from this app would constitute a relevant source of big data.
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