ArticleGenome biology2020
ncHMR detector: a computational framework to systematically reveal non-classical functions of histone modification regulators.
Article in Genome biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- ChromBERT: A foundation model for learning interpretable representations for context-specific transcriptional regulatory networks.Cell genomics · 2026Article
- PRC2 primes bivalent genes for transcription induction independent of histone methyltransferase activity.Science China. Life sciences · 2024Article
- Decoding the genomic landscape of chromatin-associated biomolecular condensates.Nature communications · 2024Article
- CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability.Tissue engineering and regenerative medicine · 2023Article
- Large-scale multi-omics analysis suggests specific roles for intragenic cohesin in transcriptional regulation.Nature communications · 2022Article
- ncHMR detector: a computational framework to systematically reveal non-classical functions of histone modification regulators.Genome biology · 2020Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, several non-classical functions of histone modification regulators (HMRs), independent of their known histone modification substrates and products, have been reported to be essential for specific cellular processes. However, there is no framework designed for identifying such functions systematically. Here, we develop ncHMR detector, the first computational framework to predict non-classical functions and cofactors of a given HMR, based on ChIP-seq data mining. We apply ncHMR detector in ChIP-seq data-rich cell types and predict non-classical functions of HMRs. Finally, we experimentally reveal that the predicted non-classical function of CBX7 is biologically significant for the maintenance of pluripotency.
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