ArticleGenetics, selection, evolution : GSE2020
An eQTL in the cystathionine beta synthase gene is linked to osteoporosis in laying hens.
Article in Genetics, selection, evolution : GSE, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Variation in cranial and caudal keel bone composition and its association with keel damage severity in laying hens.Poultry science · 2026Article
- Prolonged production cycles in commercial laying hens and its bone repercussions.Tropical animal health and production · 2026Article
- Impact of a deep-learning image reconstruction algorithm on image quality and detection of solid lung lesions.Research in diagnostic and interventional imaging · 2025Article
- The Gordon Memorial Lecture: genotype, phenotype, selection and more: improving the skeletal health of laying hens.British poultry science · 2025Article
- Article
- Genetic markers associated with bone composition in Rhode Island Red laying hens.Genetics, selection, evolution : GSE · 2023Article
- Comparative Analysis of the Temporal Impacts of Corticosterone and Simulated Production Stressors on the Metabolome of Broiler Chickens.Metabolites · 2023Article
- Article
- Relationship between Bone Quality, Egg Production and Eggshell Quality in Laying Hens at the End of an Extended Production Cycle (105 Weeks).Animals : an open access journal from MDPI · 2021Article
- No evidence that selection for egg production persistency causes loss of bone quality in laying hens.Genetics, selection, evolution : GSE · 2021Article
- Transcriptome analysis of the uterus of hens laying eggs differing in cuticle deposition.BMC genomics · 2020Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 6 countries.
Funding
Abstract
backgroundSkeletal damage is a challenge for laying hens because the physiological adaptations required for egg laying make them susceptible to osteoporosis. Previously, we showed that genetic factors explain 40% of the variation in end of lay bone quality and we detected a quantitative trait locus (QTL) of large effect on chicken chromosome 1. The aim of this study was to combine data from the commercial founder White Leghorn population and the F2 mapping population to fine-map this QTL and understand its function in terms of gene expression and physiology.
resultsSeveral single nucleotide polymorphisms on chromosome 1 between 104 and 110 Mb (galGal6) had highly significant associations with tibial breaking strength. The alternative genotypes of markers of large effect that flanked the region had tibial breaking strengths of 200.4 vs. 218.1 Newton (P < 0.002) and, in a subsequent founder generation, the higher breaking strength genotype was again associated with higher breaking strength. In a subsequent generation, cortical bone density and volume were increased in individuals with the better bone genotype but with significantly reduced medullary bone quality. The effects on cortical bone density were confirmed in a further generation and was accompanied by increased mineral maturity of the cortical bone as measured by infrared spectrometry and there was evidence of better collagen cross-linking in the cortical bone. Comparing the transcriptome of the tibia from individuals with good or poor bone quality genotypes indicated four differentially-expressed genes at the locus, one gene, cystathionine beta synthase (CBS), having a nine-fold higher expression in the genotype for low bone quality. The mechanism was cis-acting and although there was an amino-acid difference in the CBS protein between the genotypes, there was no difference in the activity of the enzyme. Plasma homocysteine concentration, the substrate of CBS, was higher in the poor bone quality genotype.
conclusionsValidated markers that predict bone strength have been defined for selective breeding and a gene was identified that may suggest alternative ways to improve bone health in addition to genetic selection. The identification of how genetic variants affect different aspects of bone turnover shows potential for translational medicine.
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