Evidence map›Paper›PMID 32093516›Full record

ReviewEpigenomics2020

Exosomal miRNAs: novel players in viral infection.

Javid Sadri Nahand, Maryam Mahjoubin-Tehran, Mohsen Moghoofei, Mohammad Hossein Pourhanifeh, Hamid Reza Mirzaei, Zatollah Asemi, Alireza Khatami, Farah Bokharaei-Salim, Hamed Mirzaei, Michael R Hamblin

Open access · greenAbstract readReview
In one paragraph

Review in Epigenomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Extracellular Vesicles: The Invisible Heroes and Villains of COVID-19 Central Neuropathology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  8. Review
  9. Viral miRNA regulation of host gene expression.Seminars in cell & developmental biology · 2023
    Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Extracellular Vesicles in Veterinary Medicine.Animals : an open access journal from MDPI · 2022
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Cell death pathways and viruses: Role of microRNAs.Molecular therapy. Nucleic acids · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Javid Sadri NahandDepartment of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Maryam Mahjoubin-TehranStudent Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohsen MoghoofeiDepartment of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Mohammad Hossein PourhanifehHalal Research Center of IRI, FDA, Tehran, Iran.
Hamid Reza MirzaeiDepartment of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Zatollah AsemiResearch Center for Biochemistry & Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Alireza KhatamiDepartment of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Farah Bokharaei-SalimDepartment of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Hamed MirzaeiResearch Center for Biochemistry & Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 40 Blossom Street, Boston, MA 02114, USA.ORCID 0000-0001-6431-4605
Iran University of Medical Sciences · IRKashan University of Medical Sciences · IRGTx (United States) · USHarvard University · USKermanshah University of Medical Sciences · IRMashhad University of Medical Sciences · IRNiroo Research Institute · IR

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
NIAID NIH HHS R01 AI050875NIAID NIH HHS R21 AI121700
6 · The paper itself

Abstract

Exosomes are secreted nanovesicles that are able to transfer their cargo (such as miRNAs) between cells. To determine to what extent exosomes and exosomal miRNAs are involved in the pathogenesis, progression and diagnosis of viral infections. The scientific literature (PubMed and Google Scholar) was searched from 1970 to 2019. The complex biogenesis of exosomes and miRNAs was reviewed. Exosomes contain both viral and host miRNAs that can be used as diagnostic biomarkers for viral diseases. Viral proteins can alter miRNAs, and conversely miRNAs can alter the host response to viral infections in a positive or negative manner. It is expected that exosomal miRNAs will be increasingly used for diagnosis, monitoring and even treatment of viral infections.

Indexed as

DNA VirusesExosomesMembrane LipidsMicroRNAsRNA VirusesVirus DiseasesMembrane LipidsMicroRNAsdiagnostic biomarkersexosomeshost responsemiRNAstherapeutic targetsviral infections

Identifiers

PMID32093516
PMCPMC7713899
OpenAlexW3008353800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.