ArticleJournal of clinical medicine2020
Relationships Among and Predictive Values of Obesity, Inflammation Markers, and Disease Severity in Pediatric Patients with Obstructive Sleep Apnea Before and After Adenotonsillectomy.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Causal analysis between altered levels of interleukins and obstructive sleep apnea.Frontiers in immunology · 2022Pooled it
- Bridging Data, Semantics, and Clinical Reasoning: A Knowledge Graph Framework for Pediatric Obstructive Sleep Apnea.Children (Basel, Switzerland) · 2026Article
- Sleep and Cytokines: A Bidirectional Dialogue Involving Rest and Immunity.Children (Basel, Switzerland) · 2026Review
- The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction: A Novel Framework to Explain Pathogenesis and Guide Treatment.Journal of the American College of Cardiology · 2025Review
- Obstructive Sleep Apnea in Overweight and Obese Children: Factors Influencing Quality of Life.Laryngoscope investigative otolaryngology · 2025Article
- Recurrence of Obstructive Sleep Apnea in Post-adenotonsillectomy Obese Pediatric Patients: A Systematic Review.Cureus · 2025Review
- Clinical significance of serum interleukin-4, interleukin-12, interleukin-13, and transforming growth factor-β levels in children with sleep-disordered breathing.American journal of translational research · 2025Article
- Alterations in Gut Microbiota Composition Are Associated with Changes in Emotional Distress in Children with Obstructive Sleep Apnea.Microorganisms · 2024Article
- Exploring the Interplay of Gut Microbiota and Systemic Inflammation in Pediatric Obstructive Sleep Apnea Syndrome and Its Impact on Blood Pressure Status: A Cross-Sectional Study.International journal of molecular sciences · 2024Article
- Overexpression of YKL40,IL-6, IL-8, TNF-α in tonsils and the role of YKL40 in childhood with obstructive sleep apnea syndrome.Scientific reports · 2024Article
- Weight Status, Autonomic Function, and Systemic Inflammation in Children with Obstructive Sleep Apnea.International journal of molecular sciences · 2024Article
- Comparative analysis of gut microbiota in children with obstructive sleep apnea: assessing the efficacy of 16S rRNA gene sequencing in metabolic function prediction based on weight status.Frontiers in endocrinology · 2024Observational
- Adenotonsillectomy-related changes in systemic inflammation among children with obstructive sleep apnea.Journal of the Chinese Medical Association : JCMA · 2023Article
- Comorbidity Profile and Predictors of Obstructive Sleep Apnea Severity and Mortality in Non-Obese Obstructive Sleep Apnea Patients.Medicina (Kaunas, Lithuania) · 2023Article
- Dietary profile of pediatric obstructive sleep apnea patients, effects of routine educational counseling, and predictors for outcomes.Frontiers in public health · 2023Observational
- Using sleep heart rate variability to investigate the sleep quality in children with obstructive sleep apnea.Frontiers in public health · 2023Article
- Novel screening model of obstructive sleep apnea for snorers with suspected NAFLD undergoing liver sonography.BMC pulmonary medicine · 2021Article
- Hypertension in Children with Obstructive Sleep Apnea Syndrome-Age, Weight Status, and Disease Severity.International journal of environmental research and public health · 2021Article
- Screening Severe Obstructive Sleep Apnea in Children with Snoring.Diagnostics (Basel, Switzerland) · 2021Article
- Different Associations between Tonsil Microbiome, Chronic Tonsillitis, and Intermittent Hypoxemia among Obstructive Sleep Apnea Children of Different Weight Status: A Pilot Case-Control Study.Journal of personalized medicine · 2021Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Both obstructive sleep apnea (OSA) and obesity are major health issues that contribute to increased systemic inflammation in children. To date, adenotonsillectomy (AT) is still the first-line treatment for childhood OSA. However, the relationships among and predictive values of obesity, inflammation, and OSA severity have not been comprehensively investigated. This prospective study investigated body mass index (BMI), serum inflammatory markers, and OSA severity before and after AT in 60 pediatric patients with OSA. At baseline, differences in levels of interleukin-6, interleukin-9, basic fibroblast growth factor, platelet-derived growth factor-BB, as well as regulated on activation, normal T cell expressed and secreted (RANTES) were significant among the various weight status and OSA severity subgroups. After 3 months postoperatively, the differences in these inflammatory markers diminished along with a decrease in OSA severity while obesity persisted. The rate of surgical cure (defined as postoperative obstructive apnea-hypopnea index < 2.0 and obstructive apnea index < 1.0) was 62%. Multivariate analysis revealed that age, BMI z-score, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein-1, and RANTES independently predicted surgical cure. Despite the significant reductions in inflammatory markers and OSA severity after AT, an inter-dependent relationship between obesity and OSA persisted. In addition to age and BMI, several inflammatory markers helped to precisely predict surgical cure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.