Evidence map›Paper›PMID 32093391›Full record

ArticleInternational journal of molecular sciences2020

Hyperbaric Oxygen Therapy Improves the Osteogenic and Vasculogenic Properties of Mesenchymal Stem Cells in the Presence of Inflammation In Vitro.

Chiara Gardin, Gerardo Bosco, Letizia Ferroni, Silvia Quartesan, Alex Rizzato, Marco Tatullo, Barbara Zavan

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Evidence-Supported HBO Therapy in Femoral Head Necrosis: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
  4. Trial
  5. Trial
  6. In Vitro Modulation of Murine Tenocyte Behavior by Hyperbaric Oxygen Therapy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Hyperbaric Oxygen Therapy for the Treatment of Bone-Related Diseases.International journal of molecular sciences · 2025
    Review
  11. Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Chiara GardinMaria Cecilia Hospital, GVM Care & Research, 48033 Cotignola (RA), Italy.
Gerardo BoscoDepartment of Biomedical Sciences, University of Padova, 35128 Padova, Italy.
Letizia FerroniMaria Cecilia Hospital, GVM Care & Research, 48033 Cotignola (RA), Italy.
Silvia QuartesanDepartment of Biomedical Sciences, University of Padova, 35128 Padova, Italy.
Alex RizzatoDepartment of Biomedical Sciences, University of Padova, 35128 Padova, Italy.
Marco TatulloDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0001-7340-0708
Barbara ZavanMaria Cecilia Hospital, GVM Care & Research, 48033 Cotignola (RA), Italy.ORCID 0000-0002-4779-4456
University of Ferrara · ITUniversity of Padua · ITUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperbaric oxygen (HBO) therapy has been reported to be beneficial for treating many conditions of inflammation-associated bone loss. The aim of this work was to in vitro investigate the effect of HBO in the course of osteogenesis of human Mesenchymal Stem Cells (MSCs) grown in a simulated pro-inflammatory environment. Cells were cultured with osteogenic differentiation factors in the presence or not of the pro-inflammatory cytokine Tumor Necrosis Factor-

Indexed as

Hyperbaric OxygenationNeovascularization, PhysiologicOsteogenesisAdipose TissueHumansInflammationMesenchymal Stem Cellsadipose-derived stem cellsbone regenerationhyperbaric oxygen therapyinflammationosteogenic differentiationvasculogenic differentiation

Identifiers

PMID32093391
PMCPMC7073059
OpenAlexW3008737608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.