ReviewInternational journal of molecular sciences2020
Persistent Breeding-Induced Endometritis in Mares - a Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 139 citations in OpenAlex.
- Antimicrobial prescribing guidelines for horses in Australia.Australian veterinary journal · 2025Guideline
- Sperm DNA fragmentation and its influence on mammalian reproduction.Nature reviews. Urology · 2026Review
- Microbiological, Molecular Diagnosis and Antimicrobial Resistance of Bordetella bronchiseptica in the Equine Reproductive Tract in Brazil.Veterinary medicine and science · 2026Article
- Intrauterine ozone therapy reduces bacterial load in mares with mixed bacterial endometritis: a longitudinal study.Veterinary research communications · 2026Article
- Beyond Routine Ultrasonography: Peri-Insemination Biomarkers in Relation to Reproductive Competence in Warmblood Mares.Animals : an open access journal from MDPI · 2026Article
- The Equine Reproductive Microbiota: Composition, Dynamics, Dysbiosis, and Implications for Fertility in Mares and Stallions.Animals : an open access journal from MDPI · 2026Review
- Equine endometrial organoids preserve tissue structure and cycle-stage transcriptional identity†.Biology of reproduction · 2026Article
- Associations between endometrial swab bacteriology and cytology findings and live foal rates in Thoroughbred broodmares in the United Kingdom.Equine veterinary journal · 2026Article
- Characterization of the Endometrial Microbiota of Healthy Mares Across the Estrous Cycle.Animals : an open access journal from MDPI · 2026Article
- The Apparent pH Stability of Antibiotic Preparations Used for Uterine Infusions in Mares.Animals : an open access journal from MDPI · 2026Article
- Equine MicroRNAs: Performance, Reproduction, and Disease.MicroRNA (Shariqah, United Arab Emirates) · 2026Review
- Impact of pituitary pars intermedia dysfunction on inflammation within the equine reproductive tract of the mare.Frontiers in veterinary science · 2026Article
- Resveratrol supplementation improves uterine immune resolution in mares susceptible to persistent breeding-induced endometritis.Frontiers in veterinary science · 2026Article
- Evidence-based interpretation of uterine cultures in mares: Linking bacterial growth patterns to endometrial inflammation.PloS one · 2026Article
- The Uterine Microbiota in Mares With Endometritis: Impacts of Antibiotic Treatment.Veterinary medicine international · 2026Article
- Uterine inflammation and lessons from large animal models of endometritis.Nature reviews. Immunology · 2025Review
- Newly isolated bacteriophages show efficacy and phage-antibiotic synergy in vitro against the equine genital pathogens Klebsiella pneumoniae and Pseudomonas aeruginosa.BMC veterinary research · 2025Article
- Powerflow Doppler Ultrasonography in the Evaluation of Mares with and Without Endometritis.Veterinary sciences · 2025Article
- Effects of Intra-uterine Ceftiofur on the Equine Uterine Microbiome.Veterinary sciences · 2025Article
- In vitro antimicrobial activity of non-traditional therapies for infectious endometritis in mares.Equine veterinary journal · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-breeding endometritis (i.e., inflammation/infection of the endometrium), is a physiological reaction taking place in the endometrium of mares within 48 hours post-breeding, aimed to clear seminal plasma, excess sperm, microorganisms, and debris from the uterine lumen in preparation for the arrival of an embryo. Mares are classified as susceptible or resistant to persistent breeding-induced endometritis (PBIE) based on their ability to clear this inflammation/infection by 48 hours post-breeding. Mares susceptible to PBIE, or those with difficulty clearing infection/inflammation, have a deficient immune response and compromised physical mechanisms of defense against infection. Molecular pathways of the innate immune response known to be involved in PBIE are discussed herein. The role of the adaptive uterine immune response on PBIE remains to be elucidated in horses. Advances in the pathobiology of microbes involved in PBIE are also revised here. Traditional and non-traditional therapeutic modalities for endometritis are contrasted and described in the context of clinical and molecular aspects. In recent years, the lack of efficacy of traditional therapeutic modalities, alongside the ever-increasing incidence of antibiotic-resistant microorganisms, has enforced the development of non-traditional therapies. Novel biological products capable of modulating the endometrial inflammatory response are also discussed here as part of the non-traditional therapies for endometritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.