ArticleMaterials (Basel, Switzerland)2020
Development of Poly(2-Methacryloyloxyethyl Phosphorylcholine)-Functionalized Hydrogels for Reducing Protein and Bacterial Adsorption.
Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Advances in GelMA Hydrogel-Enabled Angiogenic-Osteogenic Coupling: From Structural Programming to Exogenous Cue Synergy.Journal of functional biomaterials · 2026Review
- Comparative Evaluation ofVision (Basel, Switzerland) · 2023Article
- Cellulose Acetate Phthalate-Based pH-Responsive Cyclosporine A-Loaded Contact Lens for the Treatment of Dry Eye.International journal of molecular sciences · 2023Article
- Phosphorylcholine-Based Contact Lenses for Sustained Release of Resveratrol: Design, Antioxidant and Antimicrobial Performances, andACS applied materials & interfaces · 2022Article
- Recent Advances in Mechanical Reinforcement of Zwitterionic Hydrogels.Gels (Basel, Switzerland) · 2022Review
- Hydrophilic Micro- and Macroelectrodes with Antibiofouling Properties for Biomedical Applications.ACS biomaterials science & engineering · 2022Article
- Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application.Gels (Basel, Switzerland) · 2022Review
- Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance.Pharmaceutics · 2021Article
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Authors and funding
7 authors.
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Abstract
A series of hydrogels with intrinsic antifouling properties was prepared via surface-functionalization of poly(2-hydroxyethyl methacrylate) [p(HEMA)]-based hydrogels with the biomembrane-mimicking zwitterionic polymer, poly(2-methacryloyloxyethyl phosphorylcholine) [p(MPC)]. The p(MPC)-modified hydrogels have enhanced surface wettability, high water content retention (61.0%-68.3%), and good transmittance (>90%). Notably, the presence of zwitterionic MPC moieties at the hydrogel surfaces lowered the adsorption of proteins such as lysozyme and bovine serum albumin (BSA) by 73%-74% and 59%-66%, respectively, and reduced bacterial adsorption by approximately 10%-73% relative to the unmodified control. The anti-biofouling properties of the p(MPC)-functionalized hydrogels are largely attributed to the dense hydration layer formed at the hydrogel surfaces by the zwitterionic moieties. Overall, the results demonstrate that biocompatible and antifouling hydrogels based on p(HEMA)-p(MPC) structures have promising potential for application in biomedical materials.
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