Evidence map›Paper›PMID 32093221›Full record

ArticleBiomedicines2020

Long-Term Oral Administration of LLHK, LHK, and HK Alters Gene Expression Profile and Restores Age-Dependent Atrophy and Dysfunction of Rat Salivary Glands.

Yasuko Ishikawa, Tomasz D Pieczonka, Aneta M Bragiel-Pieczonka, Harumichi Seta, Tadahiro Ohkuri, Yumi Sasanuma, Yuji Nonaka

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yasuko IshikawaDepartment of Medical Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8504, Japan.ORCID 0000-0002-7927-6231
Tomasz D PieczonkaDepartment of Medical Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8504, Japan.
Aneta M Bragiel-PieczonkaDepartment of Medical Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8504, Japan.
Harumichi SetaSuntory Global Innovation Center Ltd., Suntory World Research Center, 8-1-1 Seika-cho, Soraku-gun, Kyoto 619-0284, Japan.
Tadahiro OhkuriSuntory Global Innovation Center Ltd., Suntory World Research Center, 8-1-1 Seika-cho, Soraku-gun, Kyoto 619-0284, Japan.
Yumi SasanumaSuntory Global Innovation Center Ltd., Suntory World Research Center, 8-1-1 Seika-cho, Soraku-gun, Kyoto 619-0284, Japan.
Yuji NonakaSuntory Global Innovation Center Ltd., Suntory World Research Center, 8-1-1 Seika-cho, Soraku-gun, Kyoto 619-0284, Japan.
Suntory (Japan) · JPTokushima University · JP

Funding

Japan Science and Technology Agency AS262Z01276Q
6 · The paper itself

Abstract

Xerostomia, also known as dry mouth, is caused by a reduction in salivary secretion and by changes in the composition of saliva associated with the malfunction of salivary glands. Xerostomia decreases quality of life. In the present study, we investigated the effects of peptides derived from β-lactoglobulin C on age-dependent atrophy, gene expression profiles, and the dysfunction of salivary glands. Long-term oral administration of Leu

Indexed as

AgingatrophyDNA microarraydysfunctionHKLHKpeptidessalivary glands

Identifiers

PMID32093221
PMCPMC7168239
OpenAlexW3007980740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.